Actively Recruiting
Acute Hepatitis in Children An Observational Study to Describe Symptoms and Blood Test Changes Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-07
437
Participants Needed
2
Research Sites
271 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how acute hepatitis presents in children, including the symptoms and blood test changes associated with the condition. Acute hepatitis in children can range from mild and unnoticed to severe forms that may lead to acute liver failure requiring transplantation. The study aims to better understand the frequency of various symptoms, laboratory alterations, and any complications, with a focus on how these factors vary by age group and underlying causes. The study is observational and involves collecting detailed clinical and laboratory data from pediatric patients diagnosed with acute hepatitis who access Pediatric Emergency Rooms or are hospitalized. It does not involve any experimental treatments but carefully monitors the patients' clinical course and laboratory test results, including liver enzymes and other markers of liver function. The study also assesses the occurrence of acute liver failure and its causes in the pediatric population. Participants will be followed throughout their clinical course with blood tests and symptom assessments to document the natural history and presentation of acute hepatitis in children. Researchers will analyze how symptoms and laboratory findings vary according to age and different causes of hepatitis. The study aims to complete this comprehensive evaluation within about one year, improving recognition and understanding of this condition in pediatric care settings.
CONDITIONS
Official Title
Acute Hepatitis in Pediatrics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 0 and 17 years (extremes included)
- Access to Pediatric Emergency Room and/or hospitalization
- Diagnosis of acute hepatitis
You will not qualify if you...
- Parent or guardian refuses to participate in the study
- Mild hypertransaminasemia (less than 5 times the upper limit of normal) in a patient with known chronic liver dysfunction such as liver cirrhosis
- Neonatal jaundice without hepatocyte involvement or signs of cholestasis (presence of indirect bilirubin with normal AST, ALT, and GGT)
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Azienda USL di Bologna Ospedale Maggiore
Bologna, Italy, 40124
Actively Recruiting
2
IRCCS Azienda Ospedaliero - Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
A
Arianna Dondi
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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