Actively Recruiting
Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 2: Adaptive Trial Scheduling)
Led by University of Pittsburgh · Updated on 2025-12-11
32
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
U
University of Massachusetts, Amherst
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying aphasia, a language disorder caused by stroke and other brain injuries that affects over two million people in the United States. This research focuses on improving treatments for anomia, a word-finding difficulty that is a major frustration for people with aphasia. The study aims to evaluate new approaches to naming treatment that enhance long-term retention and help patients use their naming skills in daily life. This sub-study is part of a larger project and specifically investigates the benefits of adaptive trial scheduling. Participants will take part in a randomized crossover study comparing three treatment conditions: an adaptive spacing condition, a high-item non-adaptive spacing condition, and a low-item non-adaptive spacing condition. Each participant will receive all three conditions in a random order. Treatment involves computer-based training sessions lasting 30 minutes, four times per week for ten weeks per condition. During sessions, participants practice naming pictured objects using flashcards and rate their own accuracy. Responses and accuracy are recorded, and participants can replay and repeat answers if needed. All sessions, assessments, and probes are conducted via telehealth. Participants will undergo baseline assessments, treatment sessions, and follow-up probes at 1 week, 3 months, and 6 months after treatment. There are typically 3-4 but up to 6 assessment sessions and around 120 one-on-one treatment sessions per participant over approximately one year to 18 months. The primary outcomes measured are changes in correct naming of treated and untreated pictured objects and generalization to everyday contexts. Secondary outcomes include language use in discourse, communication abilities, and motivation. The study is sponsored by the University of Pittsburgh and involves detailed monitoring through telehealth technology.
CONDITIONS
Brief Title
Adaptive Trial Scheduling in Naming Treatment for Aphasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Existing diagnosis of chronic (>6 months) aphasia after left hemisphere stroke
- Impaired performance on 2 out of 8 sections of the Comprehensive Aphasia Test
- Access to a high-speed internet connection and ability to participate in telehealth
You will not qualify if you...
- History of other acquired or progressive neurological diseases
- Significant language comprehension impairments
- Unmanaged drug or alcohol dependence
- Severe mood or behavioral disorders requiring specialized mental health treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (via telehealth)
Duration - Approximately 30 weeks total (three 10-week conditions)
Participants receive three different naming treatment conditions in a randomized order. Each condition involves ten weeks of one-on-one computer-based training four times per week via telehealth. The training consists of effortful retrieval practice using flashcard naming tasks lasting about 30 minutes per session.
120 one-on-one treatment sessions (via telehealth)
Duration - Up to 18 months total
Participants complete probe assessment sessions at baseline, 1 week, 3 months, and 6 months after each treatment condition to measure naming performance and related outcomes via telehealth.
Typically 3-4 (up to 6) assessment sessions and 24 probe sessions (via telehealth)
Trial Site Locations
Total: 1 location
1
Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260
Actively Recruiting
Research Team
A
Alyssa Kelly, M.A., CCC-SLP
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
6
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