Actively Recruiting
AI Facial Analysis Algorithm to Screening Coronary Artery Disease in High-Risk Community Population
Led by China National Center for Cardiovascular Diseases · Updated on 2026-01-06
1392
Participants Needed
3
Research Sites
17 weeks
Total Duration
On this page
Sponsors
C
China National Center for Cardiovascular Diseases
Lead Sponsor
Z
Zhoukou Specialized Disease Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a facial image-based artificial intelligence (AI) algorithm designed to screen for coronary artery disease (CAD) in high-risk community populations, including those with diabetes, hypertension, or aged over 65. The study aims to verify if the AI can accurately identify high-risk and low-risk groups by comparing the actual CAD prevalence, and to compare the AI screening detection rate with natural detection rates in a real-world cohort. Participants are divided into two groups. One group undergoes AI-based facial image screening followed by Coronary Computed Tomography Angiography (CCTA) to confirm CAD diagnosis. The other group represents a real-world setting without the AI screening and is observed to track natural CAD detection and major adverse cardiovascular events (MACE) over a six-month follow-up period. During the study, all participants receive monitoring for six months to assess CAD presence and cardiovascular outcomes, including heart attacks and revascularization procedures. Researchers will measure differences in CAD prevalence between AI-identified risk groups, detection rates of CAD, and the incidence of cardiovascular events and deaths. This follow-up period helps evaluate the AI screening’s performance compared to usual detection methods.
CONDITIONS
Brief Title
AI Facial Analysis Algorithm to Screening Coronary Artery Disease in High-Risk Community Population
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- High-risk community members with at least one of these: diabetes mellitus, hypertension, or age over 65 years
You will not qualify if you...
- Prior diagnosis of coronary heart disease, including clinical CAD, coronary artery bypass grafting, or percutaneous coronary intervention
- History of diagnosed heart failure
- Significant facial changes that interfere with AI analysis, such as plastic surgery, severe trauma, or heavy makeup
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 month
Participants in the diagnostic test cohort undergo facial image-based AI screening followed by Coronary Computed Tomography Angiography (CCTA) to verify the presence of coronary artery disease.
2 visits (in-person)
Duration - 6 months
Participants are followed for 6 months to observe the occurrence of coronary artery disease and major adverse cardiovascular events.
Periodic follow-up contacts over 6 months
Trial Site Locations
Total: 3 locations
1
Zhoukou Chuanhui District Hospital of Traditional Chinese Medicine
Zhoukou, Henan, China, 466000
Actively Recruiting
2
Zhoukou Specialized Disease Hospital
Zhoukou, Henan, China, 466000
Actively Recruiting
3
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, China, 100037
Not Yet Recruiting
Research Team
Z
zhe zheng, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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