Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Hunter F Iaccarino, Annabelle C Singer, Anthony J Martorell...
https://pubmed.ncbi.nlm.nih.gov/27929004/Actively Recruiting
Led by Alzheimer's Light LLC · Updated on 2024-08-01
2000
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating a combination of 40Hz light therapy and cognitive therapy to help people with Alzheimers disease and related cognitive disorders. This study is based on findings that gamma brainwaves, which are reduced in Alzheimers, can be increased by exposure to light flickering at 40 flashes per second. This increase in gamma waves may help clear harmful beta amyloid plaques in the brain, which are linked to the disease. Participants use a novel iPad application called AlzLife that delivers the 40Hz light therapy along with brain training exercises. They are encouraged to engage with the app for about 30 minutes daily, aiming for at least one hour per week. The study compares participants who adhere to this exercise protocol with those who do not. During the study, cognitive function is assessed through tests within the app over approximately one year. Additional evaluations include daily living activities related to Alzheimers. Researchers monitor participants interaction with the app to track adherence and study the effects on cognition, function, and quality of life over time.
CONDITIONS
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
A
Andrey Vyshedskiy, Ph.D.
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Alzheimer's Light LLC
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 1 year
Participants use the ALZLIFE iPad application which delivers a combination of 40Hz light and cognitive therapy to improve brain function.
Participants interact with the ALZLIFE app regularly, with adherence measured by exercising at least 1 hour per week.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Hunter F Iaccarino, Annabelle C Singer, Anthony J Martorell...
https://pubmed.ncbi.nlm.nih.gov/27929004/Anthony J Martorell, Abigail L Paulson, Ho-Jun Suk...
https://pubmed.ncbi.nlm.nih.gov/30879788/Helen Thomson
https://pubmed.ncbi.nlm.nih.gov/29493598/Alzheimer's Light LLC
Lead Sponsor