Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Hunter F Iaccarino, Annabelle C Singer, Anthony J Martorell...
https://pubmed.ncbi.nlm.nih.gov/27929004Actively Recruiting
Age: 50Years +
All Genders
Healthy Volunteers
ID03657745
An Observational Trial of Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Led by Alzheimer's Light LLC · Updated on 2024-08-01
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating a combination of 40Hz light therapy and cognitive therapy to help people with Alzheimer's disease and related cognitive disorders. This study is based on findings that gamma brainwaves, which are reduced in Alzheimer's, can be increased by exposure to light flickering at 40 flashes per second. This increase in gamma waves may help clear harmful beta amyloid plaques in the brain, which are linked to the disease. Participants use a novel iPad application called AlzLife that delivers the 40Hz light therapy along with brain training exercises. They are encouraged to engage with the app for about 30 minutes daily, aiming for at least one hour per week. The study compares participants who adhere to this exercise protocol with those who do not. During the study, cognitive function is assessed through tests within the app over approximately one year. Additional evaluations include daily living activities related to Alzheimer's. Researchers monitor participants’ interaction with the app to track adherence and study the effects on cognition, function, and quality of life over time.
CONDITIONS
Brief Title
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Who Can Participate
Age: 50Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Diagnosis of Alzheimer's disease
- Cognitive impairment
You will not qualify if you...
- History of epileptic seizures, including febrile seizures
- Significant eye disease such as macular degeneration requiring healthy eyes for light therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Implementation
Duration - Up to 1 year
Participants use the ALZLIFE iPad application which delivers a combination of 40Hz light and cognitive therapy to improve brain function.
Participants interact with the ALZLIFE app regularly, with adherence measured by exercising at least 1 hour per week.
Trial Site Locations
Total: 1 location
1
Andrey Vyshedskiy
Miami, Florida, United States, 33156
Actively Recruiting
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Research Team
A
Andrey Vyshedskiy, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
How flashing lights and pink noise might banish Alzheimer's, improve memory and more.
Helen Thomson
https://pubmed.ncbi.nlm.nih.gov/29493598Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.
Anthony J Martorell, Abigail L Paulson, Ho-Jun Suk...
https://pubmed.ncbi.nlm.nih.gov/30879788