Pharmacokinetic Variability Drives Palbociclib-Induced Neutropenia in Metastatic Breast Cancer Patients: Drug-Drug Interactions Are the Usual Suspects.
Fanny Leenhardt, Frédéric Fiteni, Ludovic Gauthier...
https://pubmed.ncbi.nlm.nih.gov/35456675/Actively Recruiting
Led by Institut du Cancer de Montpellier - Val d'Aurelle · Updated on 2025-04-02
992
Participants Needed
2
Research Sites
156 weeks
Total Duration
Researchers are studying circulating tumor biomarkers in blood to improve cancer diagnosis, prognosis, and treatment monitoring. This research focuses on using blood tests as a less invasive alternative to tumor biopsies, which may help detect mutations and study resistance mechanisms. The study explores how medical interventions like chemotherapy, biopsies, or surgeries affect the release of these markers into the bloodstream. The study includes various patient groups with different types of cancers such as breast, lung, colon, glioma, and sarcoma. Participants undergo blood sampling at multiple key time points, including before treatment, during treatment cycles, follow-up visits, and at disease progression. Each cohort follows specific blood collection schedules tailored to their treatment type to assess tumor markers and related biological factors. Participants will provide blood samples at prescribed intervals depending on their cancer type and treatment plan. Researchers will analyze these samples to evaluate the feasibility of different tumor biomarker tests and their potential clinical utility. The study monitors patients over several years, assessing treatment responses, toxicities, and correlations between blood markers and disease progression to better understand biomarker roles in cancer management.
CONDITIONS
Analysis of Circulating Tumor Markers in Blood
T
texier emmannuelle
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Institut du Cancer de Montpellier - Val d'Aurelle
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 years depending on cohort assignment
Participants undergo blood sampling at various key time points to analyze circulating tumor markers. The timing and frequency of blood samples vary by cohort and clinical situation.
Multiple blood sampling visits at baseline, during treatment cycles, at response assessments, and at progression or follow-up
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
13
Have more questions? Get in touch with our team for quick support
Fanny Leenhardt, Frédéric Fiteni, Ludovic Gauthier...
https://pubmed.ncbi.nlm.nih.gov/35456675/Fanny Leenhardt, Matthieu Gracia, Catherine Perrin...
https://pubmed.ncbi.nlm.nih.gov/32623316/Fanny Leenhardt, Marie Alexandre, Severine Guiu...
https://pubmed.ncbi.nlm.nih.gov/34286354/Thomas Bardol, Zahra Eslami-S, Doryan Masmoudi...
https://pubmed.ncbi.nlm.nih.gov/38132919/Keerthi Kurma, Thomas Bardol, Caroline Mollevi...
https://pubmed.ncbi.nlm.nih.gov/42001180/Fanny Leenhardt, William Jacot, Lionel Lellouche...
https://pubmed.ncbi.nlm.nih.gov/42521839/Institut du Cancer de Montpellier - Val d'Aurelle
Lead Sponsor