Actively Recruiting
Analysis of Exploring Optimized Sequential Treatment Strategies of Antibody-Drug Conjugates (ADCs) in HER2-Low-Expressing Breast Cancer
Led by Sun Yat-sen University · Updated on 2025-03-20
700
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study retrospectively analyzes the clinical data of HER2-low breast cancer (IHC 1+/2+ and FISH-negative) patients treated with sequential antibody-drug conjugates (ADCs). Key variables include patient demographics, tumor characteristics, ADC regimens (e.g., trastuzumab deruxtecan, sacituzumab govitecan), treatment sequencing, survival outcomes, and safety profiles. Genomic data (e.g., HER2 expression dynamics, TROP2 levels) are integrated to explore resistance mechanisms and prognostic biomarkers.mechanisms. This study aims to investigate the efficacy of different ADC sequential regimens in HER2-low breast cancer patients.
CONDITIONS
Official Title
Analysis of Exploring Optimized Sequential Treatment Strategies of Antibody-Drug Conjugates (ADCs) in HER2-Low-Expressing Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with HER2-low breast cancer, defined as immunohistochemistry (IHC) score of 1+ or IHC score of 2+ with negative in situ hybridization (FISH-negative)
- Received sequential administration of two or more ADCs
- Complete data for patient's character, laboratory and imaging test, treatment and follow-up are available.
You will not qualify if you...
- Concomitant with other tumor components at the time of diagnosis
- Have a history of any other malignant tumors
- Lack of complete data
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sun yat-sen University Cancer
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
Y
Yang Yalan, Bachelor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
8
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