Actively Recruiting
Analysis of the Specificity and Persistence of Nasal Immune Responses to Respiratory Viral Antigens in Immunocompromised and Healthy Cohorts
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2025-12-19
40
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to characterize nasal mucosal immunity to respiratory viruses, such as SARS-CoV-2, in immunocompromised individuals and healthy volunteers. The study involves adults of any sex, between 18 and 90 years old, including both immunocompromised patients with medical conditions or treatments that can affect immune cell functions and healthy controls with no underlying medical conditions declared, no clinical history of immunodeficiency or use of immunosuppressive medications. Researchers will compare immunocompromised participants to healthy volunteers to determine how underlying immunodeficiency and related treatments affect immune cell composition and virus-specific responses.
CONDITIONS
Official Title
Analysis of the Specificity and Persistence of Nasal Immune Responses to Respiratory Viral Antigens in Immunocompromised and Healthy Cohorts
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have signed an informed consent form.
- Aged between 18 and 90 years.
- Healthy donors must have no underlying medical conditions, no history of immunodeficiency, and no use of immunosuppressive medications.
- Immunocompromised patients include those with medical conditions or treatments causing significant immune system impairment, such as organ or stem cell transplants, ongoing immunosuppressive therapies, or documented genetic immunosuppression.
You will not qualify if you...
- Pregnant or lactating women.
- Individuals unable to provide informed consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Pavia, Italy, 27100
Actively Recruiting
Research Team
S
Stefania Mantovani, MSc
CONTACT
S
Sabrina Ottolini, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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