Actively Recruiting
ARBOspot: Characterization of Arbovirus Specific T Cell Response in Patients by Using Enzyme Linked Immunospot (ELISpot) Assays
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2026-03-04
500
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on arboviruses, a group of RNA viruses spread by insects like mosquitoes, ticks, and sandflies, which can infect humans and cause serious diseases. In Italy, certain arboviruses are common, while others are monitored closely because travel and climate change may increase their spread. The study aims to examine immune responses in patients infected with these viruses to improve diagnosis and control outbreaks. The study evaluates immunological tests, specifically the ELISpot assay, to monitor T-cell responses against arboviruses. These tests are studied alongside traditional molecular and serological methods, aiming to improve diagnosis since molecular tests have limited detection windows and serological tests can cross-react between viruses. The study uses these immunological assays to better detect and understand arbovirus infections. Participants suspected of having arbovirus infections will undergo immunological testing to assess their T-cell response over up to one year. Researchers will measure how well these T-cell based assays perform in detecting arbovirus infections. The study involves collecting samples for testing and monitoring immune responses, helping to identify patients at risk and improve disease surveillance and control. Participation includes informed consent and regular follow-up evaluations.
CONDITIONS
Brief Title
ARBOspot: Characterization of Arbovirus Specific T Cell Response in Patients by Using Enzyme Linked Immunospot (ELISpot) Assays
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old and over
- Suspected arbovirus infection
- Written informed consent and any required authorization obtained from the participant prior to performing any protocol-related procedures
You will not qualify if you...
- Any condition that might compromise safety or interfere with study results
- All other conditions not present in the inclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 year
Participants undergo immunological assays including ELISpot to characterize T-cell mediated response against arboviruses.
Multiple visits over 1 year for immunological testing
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo
Pavia, Lombardy, Italy, 27100
Actively Recruiting
Research Team
B
Baldanti
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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