Actively Recruiting
Multicenter Randomized Controlled Trial to Assess the Benefit of Tilt Table Testing in Patients with Vasovagal Syncope, TiltSYNC-trial
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-03-11
238
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the benefit of adding tilt table testing to biofeedback and standard care in patients with certain or highly likely vasovagal syncope. This condition causes fainting due to a sudden drop in heart rate and blood pressure. The trial aims to compare outcomes between patients receiving biofeedback with tilt table testing and those receiving biofeedback without tilt table testing, as current evidence on the value of tilt table testing is lacking. Participants are randomly assigned to one of two groups: one group receives biofeedback and standard care along with tilt table testing, while the other group receives biofeedback and standard care without tilt table testing. Tilt table testing is used as a diagnostic tool to provoke syncope under controlled conditions. The study explores whether this provocation improves patient management and outcomes. During the study, participants will be monitored for syncope recurrence, time until the first syncope event, near-syncope episodes, health technology assessments, and quality of life over a 12-month follow-up period after enrollment. Researchers will collect data on these outcomes to evaluate the impact of tilt table testing on the condition. The study is scheduled to begin in October 2025 and continue until March 2028.
CONDITIONS
Brief Title
Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- Certain or highly likely vasovagal syncope after guideline-based syncope evaluation
You will not qualify if you...
- Age under 18 years
- Diagnosed with reflex syncope other than vasovagal syncope
- Contraindication for tilt table testing as decided by the physician
- Presence of a learning disability
- Experiencing pre-syncope without complete loss of consciousness
- Unwillingness to provide informed consent
- Previously diagnosed patients referred for specific treatment options
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day (tilt table testing or no tilt table testing)
Participants receive biofeedback and standard of care, with or without tilt table testing depending on their assigned group.
1 baseline visit (in-person)
Duration - 12 months
Participants are followed for 12 months after enrollment to monitor syncope recurrence, near-syncope events, and quality of life.
Periodic follow-up visits throughout the year
Trial Site Locations
Total: 1 location
1
Amsterdam UMC
Amsterdam, Netherlands
Actively Recruiting
Research Team
T
Thomas T Boel, MD
E
Elvira S Amaral Gomes
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here