Actively Recruiting
Assessing the Efficacy and Safety of ctDNA-driven Selection for Anti-EGFR Retreatment in a Real World Metastatic Colorectal Cancer Patients Cohort (the REalCHALLENGE Study)
Led by Niguarda Hospital · Updated on 2026-04-17
250
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational, retrospective, international and multicenter study funded by Fondazione Oncologia Niguarda ETS to assess the efficacy of anti-EGFR rechallenge regimens in the largest real-world cohort of MSS mCRC patients screened for RAS/BRAF/PIK3CA ctDNA status on liquid biopsy within the MEN1611-02 C-PRECISE-01 trial. The study will collect molecular, clinical and outcome data of patients already available at participating centers.
CONDITIONS
Official Title
Assessing the Efficacy and Safety of ctDNA-driven Selection for Anti-EGFR Retreatment in a Real World Metastatic Colorectal Cancer Patients Cohort (the REalCHALLENGE Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with MSS RAS and BRAF wild-type (on solid tissue) metastatic colorectal cancer and screened by ctDNA within the MEN1611-02 clinical trial
- Signed informed consent from alive patients
- Availability of clinical data detailing the outcome to the first treatment received following ctDNA analysis as per MEN1611-02 screening
- Signed informed consent for molecular screening within the MEN1611-02 clinical trial
- Age 18 years or older
You will not qualify if you...
- No data available detailing outcome to the first treatment received following ctDNA analysis as per MEN1611-02 screening
- Patients enrolled and treated within the MEN1611-02 clinical trial
AI-Screening
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Trial Site Locations
Total: 1 location
1
ASST GOM Niguarda
Milan, Italia, Italy
Actively Recruiting
Research Team
S
Salvatore Siena, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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