Study of Metabolic Dysfunction-Associated Steatoic Liver Disease in Adults With Primary Hypothyroidism or Thyroid Antibody Positivity

What this Trial Is About

Researchers are investigating the prevalence of Metabolic Dysfunction-Associated Steatoic Liver Disease MASLD in adults with primary hypothyroidism, including both overt and sub-clinical forms, and comparing it to euthyroid controls among non-diabetic patients. MASLD, previously called non-alcoholic fatty liver disease, is a common chronic liver condition linked to metabolic issues like obesity and type 2 diabetes. The study also explores the relationship between Hashimoto thyroiditis and MASLD. Participants include groups with normal thyroid function, overt primary hypothyroidism, sub-clinical hypothyroidism, and those with positive thyroid auto-antibodies. All groups undergo thyroid function tests and MASLD screening using laboratory tests, abdominal ultrasound, and vibration-controlled transient elastography FibroScan. This observational study follows these assessments to estimate MASLD prevalence and its correlation with thyroid disease severity. During the study, participants will have thyroid function and liver assessments performed, including blood tests and imaging. Researchers will measure the prevalence of MASLD and examine links between hypothyroidism severity, Hashimoto thyroiditis, and liver condition over three months. The study aims to provide insights into liver disease in thyroid patients without diabetes, with participant involvement lasting through these evaluations and follow-up measurements.

Association Between Overt and Sub-clinical Primary Hypothyroidism and Metabolic Dysfunction-Associated Steatoic Liver Disease in Non-Diabetic Patients