Actively Recruiting
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
Led by University of Virginia · Updated on 2025-12-24
70
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a bike until you reach maximum effort. * Undergo blood draws * Wear a 24-hour non-invasive device that monitors blood pressure. * Drink 70mL (1/3 of a cup) of concentrated beetroot juice once
CONDITIONS
Official Title
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to communicate meaningfully with the investigator and legally competent to provide written informed consent
- Male or female aged 18 years or older
You will not qualify if you...
- Oral antibiotic use within the previous four weeks
- Oral disease or poor oral health as determined by the Oral Health Questionnaire
- Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
- Tobacco smokers
- Pregnant or lactating females
- Hypersensitivity to any ultrasound contrast agent
- Inability to perform exercise
- Unable to communicate effectively in English to the study team
- Diagnosis of chronic renal failure (GFR < 60 ml/min/1.73m)
- Taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (e.g., Cialis, Viagra), or xanthine oxidase inhibitors (e.g., Allopurinol)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UVA Student Health and Wellness Building
Charlottesville, Virginia, United States, 22903
Actively Recruiting
Research Team
C
Casey C Derella, PhD
CONTACT
M
Macy E Stahl, B.S.E.d
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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