Barts Sex-CAD Study on How Female Sex Hormones Affect Inflammation and Risk in Coronary Artery Disease

What this Trial Is About

Researchers are investigating how Coronary Artery Disease CAD, a condition where the hearts arteries become blocked or narrowed, starts and progresses, especially in women. The study aims to understand the role of inflammation and sex hormones like oestrogen and testosterone in CAD, which may explain why women have different risks and outcomes than men. This observational study focuses on patients with chest pain attending Barts Heart Centre and seeks to address gaps in knowledge about sex differences in CAD. The study involves collecting blood samples to measure sex hormone levels and various inflammatory markers from patients admitted with chest pain. Patients will also complete questionnaires about their hormone status and medical history. For those previously treated at the centre, questionnaires will be conducted by telephone. Blood samples will be analyzed at a research institute for detailed inflammatory profiles. Any significant abnormal results will be communicated to the patients care team with appropriate follow-up. Participants medical data and questionnaire responses will be securely stored and combined with routine clinical information to explore links between hormones, inflammation, and CAD outcomes. Follow-up will occur at 30 days, 1 year, and 5 years to track mortality, hospital readmissions, and major cardiac events. This comprehensive approach aims to improve understanding of CAD progression and treatment in both women and men.

Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease