Sex-Related Disparities in Cardiovascular Health Care Among Patients With Premature Atherosclerotic Cardiovascular Disease.
Michelle T Lee, Dhruv Mahtta, David J Ramsey...
https://pubmed.ncbi.nlm.nih.gov/33881448Actively Recruiting
Age: 16Years +
All Genders
ID06327984
Barts Sex-CAD Database: Do Female Sex Hormone Levels Inform Inflammatory Status and Susceptibility in Women Suffering Coronary Artery Disease?
Led by Queen Mary University of London · Updated on 2025-09-08
6000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how Coronary Artery Disease (CAD), a condition where the heart's arteries become blocked or narrowed, starts and progresses, especially in women. The study aims to understand the role of inflammation and sex hormones like oestrogen and testosterone in CAD, which may explain why women have different risks and outcomes than men. This observational study focuses on patients with chest pain attending Barts Heart Centre and seeks to address gaps in knowledge about sex differences in CAD. The study involves collecting blood samples to measure sex hormone levels and various inflammatory markers from patients admitted with chest pain. Patients will also complete questionnaires about their hormone status and medical history. For those previously treated at the centre, questionnaires will be conducted by telephone. Blood samples will be analyzed at a research institute for detailed inflammatory profiles. Any significant abnormal results will be communicated to the patient's care team with appropriate follow-up. Participants' medical data and questionnaire responses will be securely stored and combined with routine clinical information to explore links between hormones, inflammation, and CAD outcomes. Follow-up will occur at 30 days, 1 year, and 5 years to track mortality, hospital readmissions, and major cardiac events. This comprehensive approach aims to improve understanding of CAD progression and treatment in both women and men.
CONDITIONS
Brief Title
Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease
Who Can Participate
Age: 16Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Any patient presenting with chest pain
- 16 years old or older
- Presenting to Barts Heart Centre
You will not qualify if you...
- Patients under 16 years old
- Adults lacking capacity to consent
- Chest pain not related to coronary artery disease (e.g., musculoskeletal pain, aortic dissection, gastrointestinal causes, pulmonary embolism)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during hospital admission
Diagnostic Evaluation
Duration - During hospital admission and shortly after discharge
Participants have blood tests collected to assess sex hormone levels and inflammatory markers. A questionnaire is completed to gather relevant medical and menstrual history affecting hormone status.
1 blood sample collection visit (in-person) and 1 questionnaire visit (in-person or telephone)
Long-term Monitoring
Duration - Up to 5 years
Participants' health outcomes such as mortality, readmission, and cardiovascular events are monitored through electronic patient records at 30 days, 1 year, and 5 years.
No additional visits; monitoring occurs via electronic records
Trial Site Locations
Total: 1 location
1
Barts Health NHS Trust
London, United Kingdom
Actively Recruiting
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Research Team
K
Krishnaraj Rathod, MBBS PhD
A
Amrita Ahluwalia, BSc PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease.
Asad Shabbir, Krishnaraj Sinhji Rathod, Rayomand Syrus Khambata...
https://pubmed.ncbi.nlm.nih.gov/33035428The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.
Krishnaraj S Rathod, Daniel A Jones, Ajay K Jain...
https://pubmed.ncbi.nlm.nih.gov/34849299