Actively Recruiting
Biennial CEM in Women With a Personal History of Breast Cancer
Led by Wendie Berg · Updated on 2025-09-11
1500
Participants Needed
6
Research Sites
385 weeks
Total Duration
On this page
Sponsors
W
Wendie Berg
Lead Sponsor
B
Breast Cancer Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.
CONDITIONS
Official Title
Biennial CEM in Women With a Personal History of Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Asymptomatic women aged 30 to 79 years
- Personal history of breast cancer
- At least one year since any breast cancer surgery or treatment
- Scheduled for routine annual mammogram with digital breast tomosynthesis (DBT)
You will not qualify if you...
- History of moderate or severe iodinated contrast reaction
- Allergy to Benadryl if premedication is required
- Breast implants in the breasts to be screened
- Bilateral mastectomy
- History of kidney failure or estimated glomerular filtration rate (eGFR) less than 45 mL/min
- Pregnancy or lactation
- Currently receiving chemotherapy for any cancer
- Having only one kidney
- Stage 4 metastasis to visceral areas or brain
- Screening breast MRI exam within 24 months prior to current CEM exam
- Contrast-enhanced mammography exam within prior 23 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
UPMC Magee-Womens Imaging - Bethel Park
Bethel Park, Pennsylvania, United States, 15102
Actively Recruiting
2
UPMC Magee at the Lemieux Sports Complex
Cranberry Township, Pennsylvania, United States, 16066
Actively Recruiting
3
Magee Womancare Monroeville
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
4
Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
5
Hillman Cancer Center at Shadyside
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
6
UPMC West Mifflin Outpatient Center
West Mifflin, Pennsylvania, United States, 15236
Actively Recruiting
Research Team
W
Wendie Berg, MD, PhD
CONTACT
M
McKenna Rigling, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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