Actively Recruiting
Bio-CAR-T BS Study
Led by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · Updated on 2026-04-30
45
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this Study is the evaluation of post-infusion CAR-T (Chimeric Antigen Receptor T Cell) expansion and persistence in patients with DLBCL, PMBCL and ALL undergoing CAR-T therapy; and the feasibility and efficacy of the treatment in the real life practice.
CONDITIONS
Official Title
Bio-CAR-T BS Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with B-cell-ALL aged 25 years or younger, or patients with DLBCL aged 18 to 70 years, or patients with PMBCL aged 18 to 70 years who have relapsed or refractory disease after two lines of treatment
- Adequate performance status of 0 or 1
- Adequate organ function
- No active or uncontrolled infections
- No thrombo-embolisms within the last 6 months
- No clinically relevant co-morbidities such as selected cardiovascular, neurologic, or immune disorders causing organ dysfunction or requiring immunosuppressive treatment in the last 24 months
- Life expectancy of at least 3 months
You will not qualify if you...
- Patients with B-cell-ALL older than 25 years
- Patients with DLBCL younger than 18 years or older than 70 years
- Patients with PMBCL younger than 18 years or older than 70 years
- Performance status greater than 1
- Active or uncontrolled infections
- Thrombo-embolisms within the last 6 months
- Presence of clinically relevant co-morbidities such as selected cardiovascular, neurologic, or immune disorders causing organ dysfunction or requiring immunosuppressive treatment in the last 24 months
- Life expectancy less than 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
ASST Spedali Civili di Brescia
Brescia, Italy, 25123
Actively Recruiting
Research Team
D
Domenico Russo, MD
CONTACT
M
Mirko Farina, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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