Actively Recruiting
Biobank and Brain Health in Bordeaux A Population-based Cohort to Study the Biology of Brain and Cognitive Aging in Young Seniors
Led by University Hospital, Bordeaux · Updated on 2025-08-11
2050
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the biology and natural history of brain aging, focusing on cognitive aging and diseases like dementia and Alzheimer's, in adults aged 55 to 80. This population-based study aims to understand brain aging through a holistic view of environmental exposures, including nutrition, using advanced biological data methods. The study is conducted in Bordeaux and involves a representative sample of 2000 participants, emphasizing prevention and early detection of cognitive disorders. Participants will complete general health and nutrition questionnaires, undergo a computerized cognitive assessment, and provide various biological samples such as blood, urine, stool, saliva, hair, nails, and nasal swabs to create a biobank. MRI scans will be offered to volunteers aged 55 to 70. Those showing signs of cognitive or Parkinson's disorders may have additional neurological evaluations. A follow-up phase begins about three years after the initial visit, including repeated questionnaires, cognitive tests, and sample collections. Throughout the study, participants will undergo assessments of cognitive performance, nutrition, lifestyle, and immune function. Biological samples will be analyzed for metabolites and genetic data. Physical measurements and health screenings are performed during home visits. Researchers will track the availability of biobank samples and completed surveys as primary outcomes. The study includes multiple visits over several years to monitor brain health, cognitive changes, and related factors in older adults.
CONDITIONS
Brief Title
Biobank and Brain Health in Bordeaux.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Live in Bordeaux metropolitan area
- Be between 55 and 80 years old (included)
- Selected by socioeconomic level to represent the general population aged 55 to 80
- Be affiliated with the social security system
- Agree to provide a blood sample for the biobank
- For MRI sub-study: be between 55 and 75 years old (included)
- For immune response substudy: be 70 years or older or participate in the MRI study and agree to provide an additional blood sample
You will not qualify if you...
- Persons under guardianship or unable to give consent
- For MRI sub-study: contraindications to MRI such as pacemaker, valve prosthesis, other internal electrical/magnetic devices, history of neurosurgery or aneurysm, claustrophobia, or metal fragments in eyes, brain, or spinal cord
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (at home, in-person) for eligibility and initial assessments
Duration - Initial visit plus up to 3 months of dietary survey follow-ups
Participants complete questionnaires, cognitive tests, and provide biological samples including blood, urine, stool, saliva, hair, nails, and nasal swabs. Anthropometric measurements and health screenings are also conducted. MRI scans are performed for volunteers aged 55 to 70 years. A medical specialist visit may be offered for participants with cognitive disorders or Parkinson's syndrome.
Multiple visits including V1 (questionnaires and cognitive tests), V2 (sample collection and measurements at home), V3 (MRI scan for eligible volunteers), and V4 and V5 (dietary surveys by telephone at 4 and 8 months after V1)
Duration - Several visits over approximately 1 year starting 3 years after baseline
Approximately three years after baseline, participants undergo a follow-up phase with repeated questionnaires, cognitive testing, dietary surveys, biological sample collections, and some repeated health measurements to monitor brain and cognitive aging.
6 visits including V7 (general questionnaire and cognitive battery), V8 (sample collection and measurements), and V9, V10, V11 (dietary surveys at 4, 8, and 12 months after V7)
Trial Site Locations
Total: 1 location
1
University Hospital of Bordeaux
Bordeaux, Bordeaux, France, 33300
Actively Recruiting
Research Team
C
Cécilia SAMIERI, Dr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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