Study of Bone Marrow Aspirate Concentrate Injection During Lumbar Microdiscectomy Surgery in Adults with Lumbar Disc Herniation

What this Trial Is About

Researchers are studying whether adding a bone marrow aspirate concentrate BMAC injection during lumbar microdiscectomy surgery can improve recovery in adults with lumbar disc herniation. The trial aims to see if the injection leads to better disc tissue health on MRI scans and greater improvement in pain and disability compared to surgery alone. Adults aged 18 and older scheduled for this surgery are eligible to participate. Participants are randomly assigned to receive either the standard lumbar microdiscectomy surgery with a one-time 1-2 cc intradiscal BMAC injection during surgery or the same surgery without the injection. The study compares these two groups to evaluate the effect of the BMAC injection on disc health and recovery outcomes. Participants will have the surgery with or without the injection and complete pain and disability questionnaires at multiple times over two years. MRI scans will be performed at the start and at follow-up visits to assess disc structure and tissue health. Leftover disc or bone marrow tissue samples from surgery will be collected for analysis. Researchers will measure changes in disc hydration, proteoglycan content, disc height, and other imaging and clinical outcomes over 2 years to assess treatment effects.

Biologic Injection For Adults With Lumbar Disc Herniation