Study of Blood Biomarkers and Hemorrhage Risk in Cerebral Arteriovenous Malformations

What this Trial Is About

Cerebral arteriovenous malformations AVMs are tangled abnormal blood vessels called nidus that directly connect arteries to veins, bypassing normal circulation. These malformations are a significant cause of hemorrhagic stroke. Researchers are studying whether bleeding from cerebral AVMs is linked to small vessels near the nidus, possibly involving white blood cells and platelet-related microvascular issues. This observational study examines the relationship between blood biomarkers and the risk of bleeding in cerebral AVMs. Participants include patients with cerebral AVMs who are undergoing treatment such as surgery or endovascular methods, or who are being clinically monitored without intervention. The study measures markers related to blood vessel lining, platelets, neutrophils, and new blood vessel growth at six months to understand their connection to bleeding risk. Participants will provide blood samples that researchers analyze for specific biomarkers related to AVM prognosis. The main outcomes focus on associations between these blood markers and bleeding risk over six months. The study involves monitoring health status and collecting data without administering treatments, with participation length depending on individual follow-up schedules.

Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations