Actively Recruiting
Biology of Juvenile Myoclonic Epilepsy
Led by King's College London · Updated on 2025-09-05
1000
Participants Needed
15
Research Sites
494 weeks
Total Duration
On this page
Sponsors
K
King's College London
Lead Sponsor
K
King's College Hospital NHS Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.
CONDITIONS
Official Title
Biology of Juvenile Myoclonic Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Juvenile Myoclonic Epilepsy following consensus criteria
- Age at myoclonus onset between 10 and 25 years
- Seizures mainly or only early morning myoclonus of upper limbs
- EEG showing interictal generalized spikes or polyspike and waves with normal background
- Current age between 10 and 40 years
You will not qualify if you...
- Myoclonus only linked to carbamazepine or lamotrigine treatment
- EEG showing mainly focal interictal epileptiform discharges or abnormal background
- Signs of progressive or symptomatic myoclonus epilepsy or focal seizures
- Global learning disability
- Dysmorphic syndrome
- Unable to give informed consent
- Self-referrals are not accepted for this study
AI-Screening
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Trial Site Locations
Total: 15 locations
1
Mount Sinai-Beth Israel Medical Center
New York, New York, United States, 10003
Completed
2
St Luke's Roosevelt Hospital
New York, New York, United States, 10025
Completed
3
Nationwide Children's Hospital
Columbus, Ohio, United States, 43125
Completed
4
Hospital for Sick Kids
Toronto, Ontario, Canada, M5G 0A4
Actively Recruiting
5
Charles University
Prague, Czechia, 116 36
Actively Recruiting
6
Danish National Epilepsy Centre
Dianalund, Denmark, 4293
Actively Recruiting
7
Tallinn Children's Hospital
Tallinn, Estonia, 13419
Actively Recruiting
8
University Robert Debré
Paris, France, 75019
Actively Recruiting
9
Commissione Genetica Lega Italiana contro l'Epilepssia
Roma, Italy, 00198
Actively Recruiting
10
Vestre Viken Health Trust, Oslo
Drammen, Norway, 3004
Actively Recruiting
11
Walton Centre for Neurology and Neurosurgery
Liverpool, United Kingdom, L9 7LJ
Actively Recruiting
12
Royal London Hospital
London, United Kingdom, E1 1BZ
Actively Recruiting
13
St Thomas' Hospital
London, United Kingdom, SE1 9HT
Actively Recruiting
14
King's College Hospital NHS Trust
London, United Kingdom, SE5 9RS
Actively Recruiting
15
Swansea University
Swansea, United Kingdom, SA2 8PP
Actively Recruiting
Research Team
D
Deb K Pal, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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