Actively Recruiting
Biomarkers of Reaction To HIIT Exercise
Led by VA Office of Research and Development · Updated on 2026-03-27
55
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
A
Atlanta VA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.
CONDITIONS
Official Title
Biomarkers of Reaction To HIIT Exercise
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic left or right subcortical stroke at least 6 months after a cardiovascular accident
- Lower extremity motor impairment causing walking speed less than 0.6 m/s during a 10-meter walk
- Veteran status
You will not qualify if you...
- MRI contraindications such as implanted cardiac pacemakers or severe claustrophobia
- Neurodegenerative conditions other than stroke causing lower extremity impairment
- Visual or auditory impairments that may interfere with study procedures
- Medical conditions that prevent participation in physical exercise programs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033-4004
Actively Recruiting
Research Team
L
Lisa C Krishnamurthy, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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