Actively Recruiting
The Bipolar Lithium Imaging Scan Study.
Led by Leiden University Medical Center · Updated on 2024-12-13
80
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
Sponsors
L
Leiden University Medical Center
Lead Sponsor
P
PsyQ
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main goal of this study is to determine if brain lithium-concentrations predict clinical lithium treatment-response. Secondary, to study correlations between intracerebral distribution-patterns of lithium with clinical treatment outcome. Brain lithium concentrations will be measured using ultra-high field (7 Tesla) lithium magnetic resonance (MR) imaging, which has recently been introduced. Determining lithium-concentrations in the brain has been difficult so far due to lithium's relatively low concentration (compared to protons, which are targeted in conventional MRI). 7T lithium MR imaging has the potential to produce much more detailed MR images compared with previous studies, for the first time. The BLISS study is expected to yield new insights, helping to better understand why clinical lithium response varies between individuals.
CONDITIONS
Official Title
The Bipolar Lithium Imaging Scan Study.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or above
- Clinical diagnosis of bipolar disorder type I or type II
- Reached stable therapeutic serum lithium concentrations within four weeks prior to participation (0.6-1.0 mM for age up to 65 years; 0.4-0.8 mM for age 65 years and above)
- Provided written informed consent
You will not qualify if you...
- Insufficient comprehension of the Dutch language
- Unable to provide informed consent
- Drug or alcohol abuse within two weeks prior to participation
- Any exclusion criteria for MR imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Leiden University Medical Center
Leiden, South Holland, Netherlands, 2333 ZA
Actively Recruiting
Research Team
E
E Boere
CONTACT
O
Onderzoekscentrum Psychiatrie, OZC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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