Actively Recruiting

Age: 7Years +
All Genders
Healthy Volunteers
ID03025074

Virology, Immunology and Mechanisms of Liver Disease in Patients With Hepatitis C and Other Liver Diseases

Led by State University of New York at Buffalo · Updated on 2025-08-27

1000

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are collecting biological samples from patients with various liver diseases including Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Hepatitis C (HCV), Hepatitis B (HBV), and Human Immunodeficiency Virus (HIV). This biorepository aims to support research by providing high-quality specimens to help advance understanding and treatment of liver diseases. The project also promotes collaboration among clinicians and researchers and supports training for new investigators to improve patient health nationwide. The biorepository collects blood samples such as serum, plasma, buffy coat, and liver tissue from patients seen in clinics, including rarer liver diseases. Samples are stored and made available for future research to facilitate new discoveries in liver disease mechanisms and therapies. Both children and teenagers are considered special populations for this protocol, and negative control samples from individuals without liver disease are also included. Participants provide samples during clinic visits, and the main measure tracked is the number of samples collected over 52 weeks. This observational study involves no treatment but focuses on gathering clinically annotated human specimens. Participation may involve periodic blood draws and sharing medical information to contribute to liver disease research. The study is open to all genders aged 7 years and older and continues until December 2099.

CONDITIONS

Brief Title

Blood Collection Biorepository for Liver Disease Research

Who Can Participate

Age: 7Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants with or without liver diseases including viral hepatitis, liver cancer, NASH, and negative controls
  • Children and teenagers are special populations considered
  • Participants aged 7 years and older
Not Eligible

You will not qualify if you...

  • Adults unable to consent
  • Infants
  • Pregnant women
  • Prisoners

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Sample Collection

Duration - Up to 52 weeks

Participants provide biological samples to support research on liver diseases.

1 to multiple visits depending on sample collection schedule

Trial Site Locations

Total: 1 location

1

University at Buffalo, Buffalo General Medical Center

Buffalo, New York, United States, 14203

Actively Recruiting

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Research Team

B

Barbara Bauer, BA

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Response to Commentary on Zeremski et al. (2016): Improvements in HCV-related Knowledge Among Substance Users on Opioid Agonist Therapy After an Educational Intervention.

Marija Zeremski, Clewert Sylvester, Andrew H Talal

https://pubmed.ncbi.nlm.nih.gov/27685683

Diagnostic accuracy of intracellular uptake rates calculated using dynamic Gd-EOB-DTPA-enhanced MRI for hepatic fibrosis stage.

Krishna Juluru, Andrew H Talal, Rhonda K Yantiss...

https://pubmed.ncbi.nlm.nih.gov/27527820

Development and validation of a UPLC-MS/MS method for the simultaneous determination of paritaprevir and ritonavir in rat liver.

Andrew J Ocque, Colleen E Hagler, Robin Difrancesco...

https://pubmed.ncbi.nlm.nih.gov/27277877

Improvements in HCV-related Knowledge Among Substance Users on Opioid Agonist Therapy After an Educational Intervention.

Marija Zeremski, Roberto Zavala, Rositsa B Dimova...

https://pubmed.ncbi.nlm.nih.gov/26881485

Intrahepatic and Peripheral CXCL10 Expression in Hepatitis C Virus-Infected Patients Treated With Telaprevir, Pegylated Interferon, and Ribavirin.

Marija Zeremski, Rositsa B Dimova, Samantha Benjamin...

https://pubmed.ncbi.nlm.nih.gov/25512630