Actively Recruiting
Blood Lipid Responses to Diet Macronutrients
Led by University of Oxford · Updated on 2026-05-11
60
Participants Needed
2
Research Sites
254 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown. In a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism will be examined.
CONDITIONS
Official Title
Blood Lipid Responses to Diet Macronutrients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent for participation
- Male or female aged 18 to 65 years
- Body mass index (BMI) between 19 and 35 kg/m2
- No medical condition or relevant drug therapy affecting liver, fat tissue, or heart metabolism
- Weight stable for the previous 3 months
You will not qualify if you...
- Younger than 18 or older than 65 years
- Body mass index (BMI) less than 19 or greater than 35 kg/m2
- Blood hemoglobin less than 135 mg/dL for men and less than 120 mg/dL for women
- Donated or lost 250 mL or more of blood in the last 2 months
- On a weight loss diet or lost more than 5% of body weight in the last 3 months
- Currently or recently following a diet with notably altered macronutrient content (e.g., high-fat, low-carbohydrate)
- Gained more than 5% body weight in the last 3 months
- Any metabolic condition or relevant drug therapy
- Current smoker
- History of alcoholism or daily alcohol intake over 30 g for men and 20 g for women
- History of albumin allergy
- Pregnant or nursing mothers
- History of severe claustrophobia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
2
Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, United Kingdom, OX3 7LE
Actively Recruiting
Research Team
D
David J Dearlove
CONTACT
L
Leane Hodson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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