Idiopathic intracranial hypertension: relationship to depression, anxiety, and quality of life.
J J Kleinschmidt, K B Digre, R Hanover
https://pubmed.ncbi.nlm.nih.gov/10668690Actively Recruiting
Age: 18Years +
All Genders
ID06913712
Evolution of Body Mass Index in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment Retrospective and Prospective Study
Led by University of Valencia · Updated on 2026-04-22
25
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore the relationship between body mass index (BMI) changes and treatment response in people with Idiopathic Intracranial Hypertension (IIH). The study seeks to determine the BMI level at which IIH occurs, how much BMI needs to be lowered to resolve the condition, and how patients who do not lose weight or continue gaining weight respond to treatments such as Acetazolamide or cerebrospinal fluid (CSF) diversion procedures. It addresses the challenges patients face with weight loss and the complications linked to treatment failures and shunt system malfunctions. Participants will be observed without receiving medication to assist weight loss. Their weight will be recorded every three months and correlated with their response to treatments like weight loss alone, diuretic drugs (Acetazolamide), or surgical CSF diversion methods including lumboperitoneal or ventriculoperitoneal shunts. Bariatric surgery and endocrinology-recommended diets may be part of patient care, but weight loss medication is not used or approved in this study. During the study, participants will have their weight tracked regularly for about one year to assess how they respond to the various treatments. Researchers will measure treatment response over this period to understand the impact of BMI changes on IIH. The study does not provide treatments but observes existing approaches and their outcomes. The goal is to establish clearer BMI targets to help patients manage the disease effectively.
CONDITIONS
Brief Title
BMI in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older at the time of enrollment
- Confirmed diagnosis of Idiopathic Intracranial Hypertension based on Dandy criteria
- Diagnostic process excludes other causes of increased intracranial pressure ensuring idiopathic cases
You will not qualify if you...
- Diagnosis of headache disorders other than Idiopathic Intracranial Hypertension such as tension-type headache or Chiari I malformation
- Presence of secondary causes of increased intracranial pressure like structural brain abnormalities, venous sinus thrombosis, or medication-induced factors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Monitoring
Duration - Approximately 1 year
Participants with Idiopathic Intracranial Hypertension have their weight recorded every three months to assess response to different treatment modalities without additional medication for weight loss.
Quarterly visits every 3 months
Trial Site Locations
Total: 1 location
1
Consorcio Hospital General Universitario de Valencia
Valencia, Valencia, Spain, 46015
Actively Recruiting
Loading map...
Research Team
V
Vicente Vanaclocha, Professor
T
Teresa Moratal, Secretary
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Association of Amount of Weight Lost After Bariatric Surgery With Intracranial Pressure in Women With Idiopathic Intracranial Hypertension.
Susan P Mollan, James L Mitchell, Andreas Yiangou...
https://pubmed.ncbi.nlm.nih.gov/35790425Weight gain and recurrence in idiopathic intracranial hypertension: a case-control study.
M W Ko, S C Chang, M A Ridha...
https://pubmed.ncbi.nlm.nih.gov/21536635The Health Economic Evaluation of Bariatric Surgery Versus a Community Weight Management Intervention Analysis from the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT).
Magda Aguiar, Emma Frew, Susan P Mollan...
https://pubmed.ncbi.nlm.nih.gov/33946177Cost-effectiveness of bariatric surgery versus community weight management to treat obesity-related idiopathic intracranial hypertension: evidence from a single-payer healthcare system.
Laura Elliot, Emma Frew, Susan P Mollan...
https://pubmed.ncbi.nlm.nih.gov/33952427Bariatric Surgery as a Viable Treatment for Idiopathic Intracranial Hypertension: a Case Series and Review of Literature.
Vimaladhithan Mahendran, Pol Ricart, Fridi Levine...
https://pubmed.ncbi.nlm.nih.gov/34322839Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial.
Susan P Mollan, James L Mitchell, Ryan S Ottridge...
https://pubmed.ncbi.nlm.nih.gov/33900360Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension.
Connar S J Westgate, Keira Markey, James L Mitchell...
https://pubmed.ncbi.nlm.nih.gov/35584002Long Term Effects of Metabolic and Bariatric Surgery on Idiopathic Intracranial Hypertension.
Adam Abu-Abeid, Anat Bendayan, Jawad Tome...
https://pubmed.ncbi.nlm.nih.gov/37351765Midterm benefits of metabolic surgery on symptom remission and medication use in patients with pseudotumor cerebri.
Luis Felipe Okida, Tara Salimi, Rene Aleman...
https://pubmed.ncbi.nlm.nih.gov/36549974