Memory for remote events in alcoholics.
M S Albert, N Butters, J Brandt
https://pubmed.ncbi.nlm.nih.gov/7278254Completed
All Genders
Healthy Volunteers
ID00001288
Cerebral Blood Flow Studies of Language and Memory
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2008-03-04
303
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. This study is designed to use positron emission tomography (PET) with radioactive water (H215O) to determine the areas of the brain associated with memory and language. Patients participating in the study will be made up of normal volunteers, patients with epilepsy, and patients with other abnormalities related to the surface of the brain (non-epileptic focal cortical dysfunctions).
CONDITIONS
Official Title
Brain Blood Flow Studies of Language and Memory
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
INCLUSION CRITERIA:
Normal Volunteers:
The desired age range is 18 to 55 years.
Subjects will have no history of head injury or other neurological disease and must not be taking any medication.
Female subjects of childbearing potential will be administered a pregnancy test; these subjects will not be eligible for the study requiring 2 scans.
All volunteers will read and sign the consent form.
Patients:
Patients will be selected from among those referred to the Clinical Epilepsy Section, NINDS for evaluation.
EXCLUSION CRITERIA:
Patients with evidence of a progressive intracranial process, who are taking any drugs (except AEDs) that might affect the results, or active systemic disease will be excluded.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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B Milner
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S E Petersen, P T Fox, M I Posner...
https://pubmed.ncbi.nlm.nih.gov/3277066