Actively Recruiting
Brain Imaging of Cognition Inn Schizophrenia and Depression
Led by The Royal Ottawa Mental Health Centre · Updated on 2026-03-23
90
Participants Needed
1
Research Sites
355 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the stabilization of other clinical symptoms. Verbal memory and emotion regulation are two important cognitive domains that are impaired in schizophrenia and depression and are associated with patients' functional outcomes. In this study, brain imaging is used to investigate the brain mechanisms underlying these cognitive deficits in these populations.
CONDITIONS
Official Title
Brain Imaging of Cognition Inn Schizophrenia and Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- Current IQ above 70 measured by the Wechsler Abbreviated Scale of Intelligence (WASI)
- Ability to read and speak fluent English
- Diagnosis of schizophrenia, schizoaffective disorder, or major depressive disorder
- Stable medication use for more than one month
You will not qualify if you...
- Significant neurological or other medical disorders causing cognitive impairment
- Substance abuse or dependence within the past 3 months
- Any contraindications for MRI (e.g., metallic head implant, history of seizure, pacemaker)
- Decisional incapacity requiring a guardian
- Taking medications with Anticholinergic Burden (ACB) Score 3 or daily benzodiazepines
- Severe symptoms at enrollment defined as MADRS score greater than 34 for depression or PANSS score greater than 95 for schizophrenia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Royal Ottawa Mental Health Center
Ottawa, Ontario, Canada, K1Z 7K4
Actively Recruiting
Research Team
S
Synthia Guimond, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here