Actively Recruiting
Breast Cancer Evolution During Neoadjuvant Systemic Therapy
Led by Royal Marsden NHS Foundation Trust · Updated on 2026-04-16
500
Participants Needed
1
Research Sites
517 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
BELIEVE is a translational research study that aims to collect samples of breast cancer tissue and blood from individuals undergoing breast cancer treatment (such as chemotherapy, targeted therapy and immunotherapy) before surgery. In certain cases, MRI scans and stool samples will also be obtained before and during treatment. The samples collected from this study will be used for molecular and genetic research to understand why some cancers respond very well to anticancer treatments, and some do not, develop novel ways of accurately measuring response during treatment, as well as identify which patients are at a higher risk of the cancer coming back after surgery.
CONDITIONS
Official Title
Breast Cancer Evolution During Neoadjuvant Systemic Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed non-metastatic invasive breast cancer
- Suitable for, but have not started, neoadjuvant chemotherapy, targeted therapy, or immunotherapy
- If HER2-negative, suitable for upfront taxane chemotherapy
- If HER2-positive, suitable for anti-HER2 targeted therapy
- Aged 18 years or older
- Provided written informed consent to participate
You will not qualify if you...
- Metastatic breast cancer at diagnosis
- Treatment with neoadjuvant endocrine therapy only
- Any psychological, familial, or social condition that may affect compliance with the study protocol and follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Royal Marsden NHS Foundation Trust
London, United Kingdom, SW3 6JJ
Actively Recruiting
Research Team
B
BELIEVE Trial Manager
CONTACT
S
Sophie Cooke
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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