Long-term outcome of cardiac function in a population-based cohort of breast cancer survivors: A cross-sectional study.
Liselotte M Boerman, Saskia W M C Maass, Peter van der Meer...
https://pubmed.ncbi.nlm.nih.gov/28601706Actively Recruiting
FEMALE
Healthy Volunteers
ID05851053
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Led by University Medical Center Groningen · Updated on 2024-05-29
455
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University Medical Center Groningen
Lead Sponsor
Z
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether women who survived breast cancer at least five years ago and received chemotherapy and/or radiotherapy are at increased risk of long-term heart problems. This study compares cardiac function in these survivors to a similar group of women without cancer, aiming to find if monitoring heart health in breast cancer survivors is needed and to identify those at highest risk. It uses a longitudinal matched cohort design within primary care. The study involves two groups: breast cancer survivors diagnosed at least five years ago who underwent chemotherapy and/or radiotherapy, and an age- and general practitioner-matched group with no cancer history. The main assessment involves echocardiography, which measures heart dimensions, left and right ventricle function, valve status, heart rhythm, and other cardiac parameters. Participants will undergo echocardiography from October 2022 through December 2024 to assess left ventricular systolic dysfunction and other heart function markers. Researchers will track changes in heart function, cardiovascular diseases, and heart failure symptoms during the study. The study is observational and takes place in primary care, focusing on long-term outcomes in breast cancer survivors compared to matched controls.
CONDITIONS
Brief Title
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Who Can Participate
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Female patients who participated in the BLOC-I study
- Diagnosed with stage I-III breast cancer or local/locoregional recurrence at least 5 years ago
- Received chemotherapy and/or radiotherapy treatment
You will not qualify if you...
- Unable to travel to the hospital due to severe mental or physical illness as assessed by their GP
- Metastatic disease at the time of breast cancer diagnosis
- Breast cancer treatment after 80 years of age
- History of treatment for other types of cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Approximately 2 years
Participants undergo echocardiography to assess heart dimensions, left and right ventricle function, valve function, and other cardiac parameters.
Periodic visits for echocardiography assessments during the study period
Long-term Monitoring
Duration - Through study completion (from October 2022 to December 2024)
Participants are observed for the course of cardiac function, cardiovascular diseases, and symptoms of heart failure.
Follow-up visits aligned with diagnostic evaluations
Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Netherlands, 9700 AD
Actively Recruiting
Loading map...
Research Team
D
Daan Brandenbarg, PhD
L
Laurine T van der Wal, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here