Actively Recruiting
Breast Cancer Subtype Characterization Through Patient's Derived Organoids.
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2024-03-18
306
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Development of tools to predict patients chemo-sensitivity and identification of corresponding biomarkers is an urgent challenge for BC patients lacking targeted therapies, such as TNBC, or for patients experiencing relapse after adjuvant chemotherapy or targeted therapies. The refinement of 3D-cultivation techniques, experienced in the last decade, has allowed cultivation of patients-derived cancer cells in organotypic structures, named patient-derived organoids (PDO), which preserve histologic, genomic and transcriptomic features of primary tumors. PDO allow propagation, pharmacological treatment and genetic manipulation of patients-derived cancer cells in a close to physiology setting, thus representing a promising tool in the development of personalized therapies
CONDITIONS
Official Title
Breast Cancer Subtype Characterization Through Patient's Derived Organoids.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women diagnosed with primary breast cancer eligible for surgical tumor removal
- Age between 18 and 70 years
- Newly diagnosed breast tumors
- Tumor size of at least 1.5 cm in diameter
You will not qualify if you...
- Breast cancer diagnosed during pregnancy
- Previous neoadjuvant chemotherapy treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Fondazione Policlinico A. Gemelli
Roma, Italy, 00168
Actively Recruiting
Research Team
A
Alba Di Leone, Doc
CONTACT
C
Chiara Naro, Doc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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