Study of Calciphylaxis in Adults with Chronic Kidney Disease in the Danish Calciphylaxis Research Initiative DanCaRI Comparing Patients With and Without Calciphylaxis and Including Healthy Adults

What this Trial Is About

Calciphylaxis is a rare and serious condition characterized by calcification in small blood vessels of the skin, mainly affecting people with chronic kidney disease CKD. Knowledge about its causes and risk factors is limited, and there is currently no proven effective treatment. This research aims to compare patients with CKD who develop calciphylaxis to those with CKD who do not, to learn more that may help prevent and detect the condition earlier and guide new treatments. The study includes a retrospective part covering two years and a prospective follow-up period of three years. It involves three groups patients with CKD and calciphylaxis, matched patients with CKD without calciphylaxis, and a healthy reference group for comparison. Clinical data and biological samples are collected from participants to support this research. Participants will be monitored for three years, during which researchers will assess outcomes including all-cause mortality, pain severity, quality of life, hospitalizations, and wound status related to calciphylaxis. The study collects detailed information and samples to help understand the disease better and improve future care. Participation involves providing consent and being able to join clinical assessments as determined by investigators.

Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI)