Study on How Cannabis Use and Stopping Cannabis Affects Sleep, Body Clock, and Light Sensitivity in Young Adults Aged 18 to 25

What this Trial Is About

This research aims to understand how cannabis use and stopping cannabis affect sleep, body clock rhythms, and sensitivity to light in young adults. The main questions focus on whether cannabis use and discontinuation change sleep drive and how they impact light sensitivity and the timing of the bodys internal clock. The study compares regular cannabis users with non-users to explore these effects. Participants in the cannabis-using group will undergo a 1-week baseline period involving at-home monitoring with sleep diaries, actigraphy, and an EEG headband. They will then take part in a 4-week cannabis discontinuation protocol with support from a clinician and abstain from cannabis use. Both cannabis users and non-users will participate in two 2-night lab visits, one before and one after the discontinuation phase for cannabis users, to assess circadian phase and light sensitivity. Throughout the study, participants will complete various assessments including sleep tracking at home and detailed lab evaluations of circadian rhythms and retinal response. Researchers will measure homeostatic sleep drive, circadian photosensitivity, retinal responsivity, and circadian phase at different stages. The study lasts about five weeks for cannabis users and includes ongoing monitoring to understand changes related to cannabis use and abstinence.

Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults