Actively Recruiting
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
Led by University of Pittsburgh · Updated on 2026-04-06
180
Participants Needed
1
Research Sites
215 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1. Does cannabis use and discontinuation impact sleep drive? 2. Does cannabis use and discontinuation impact light sensitivity and circadian phase?
CONDITIONS
Official Title
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-25 years
- Physically and psychiatrically healthy as determined by study assessments
- Cannabis-Using group: Regular cannabis use (6-29 days/month or daily) for past 3 months
- Cannabis-Using group: Willingness to stop cannabis use for 4 weeks
- Control group: No cannabis use in past 3 months
- Control group: No daily or near-daily cannabis use in past year
- Control group: No history of alcohol or substance use disorders
- Control group: No current sleep disorders including insomnia or delayed sleep phase disorder
- Provision of written informed consent
You will not qualify if you...
- Significant or unstable acute or chronic medical conditions, including central nervous system disorders, heart disease, liver disease, migraine, peptic ulcer disease, inflammatory bowel disease, renal failure, arthritis, diabetes, and other endocrine disorders
- Seizure disorder due to risk for cannabis withdrawal symptoms
- Eye or retinal conditions like diabetic retinopathy or glaucoma
- Past or current bipolar disorder or psychotic disorders
- Daily alcohol use or regular use of illicit substances other than cannabis in past 3 months
- Past or current substance use disorders other than cannabis, nicotine, or mild alcohol use disorder
- Current sleep disorders other than insomnia and delayed sleep phase disorder, including narcolepsy, restless legs syndrome, obstructive sleep apnea, and night shift work
- Travel across 2 or more time zones in past 60 days
- Use of benzodiazepines or non-benzodiazepine hypnotic drugs
- Use of Pennsylvania Medical Marijuana Card for qualifying medical conditions other than mental health conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Western Psychiatric Hospital (Thomas Detre Hall)
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
B
Brant P Hasler, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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