Actively Recruiting
Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods
Led by Brown University · Updated on 2024-08-06
350
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Brown University
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of different types of cannabis on alcohol consumption in heavy episodic drinkers who use cannabis weekly. This study compares the impact of THC-dominant cannabis, CBD-dominant cannabis, and placebo on subsequent drinking behavior using a repeated measures experimental design. Participants will receive cannabis simultaneously with either an alcohol-priming dose or an alcohol placebo, aiming to better understand how specific cannabinoids influence alcohol use and related risks. Participants will be randomized to receive one of several interventions: a THC-dominant cannabis dose (9.53% THC and 0.09% CBD), a CBD-dominant cannabis dose (0.35% THC and 11.27% CBD), or a placebo cannabis dose, all smoked using a handheld pipe. Alcohol will be given as a priming drink designed to raise blood alcohol levels to 0.03 g/dl or as a placebo beverage consisting mainly of juice with a trace of alcohol for masking. The study includes a baseline session, three experimental sessions, and a four-week follow-up period using a smartphone application to monitor participants in their natural environment. During the study, participants will complete alcohol choice tasks to measure the amount of alcohol consumed after smoking cannabis or placebo. Researchers will assess drinking behavior over two hours after cannabis use and track participants' alcohol use and related behaviors during the four-week follow-up. Safety measures include breath alcohol tests at each visit and monitoring for adherence to study protocols. The study aims to enroll up to 350 participants to achieve a final sample of 200 with complete data.
CONDITIONS
Brief Title
Cannabis' Impact on Alcohol Consumption
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 to 50 years
- English-speaking
- Smoked cannabis in the past two months
- Engaged in heavy drinking in the past two months
- In good physical health and weighing less than 250 lbs
- Zero breath alcohol at each visit
You will not qualify if you...
- Positive pregnancy test
- Currently nursing
- Positive urine toxicology screen for drugs other than cannabis
- Interest in quitting or receiving treatment for cannabis or alcohol use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants complete initial assessments and baseline measurements before experimental sessions.
1 visit (in-person)
Duration - 3 sessions over several weeks
Participants attend three sessions where they receive different cannabis and alcohol doses to assess effects on alcohol consumption.
3 visits (in-person)
Duration - 4 weeks
Participants are monitored for 4 weeks using a smartphone app to assess drinking behavior in their daily environment after experimental sessions.
Continuous monitoring via smartphone app
Trial Site Locations
Total: 1 location
1
Brown University
Providence, Rhode Island, United States, 02912
Actively Recruiting
Research Team
J
Jane Metrik, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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