Late cardiac adverse events in patients with cancer treated with immune checkpoint inhibitors.
Charles Dolladille, Stephane Ederhy, Stéphane Allouche...
https://pubmed.ncbi.nlm.nih.gov/31988143/Actively Recruiting
Led by Assistance Publique Hopitaux De Marseille · Updated on 2022-09-21
530
Participants Needed
1
Research Sites
26 weeks
Total Duration
The Mediterranean Group of Cardio-Oncology GMEDICO is conducting research to understand the cardiovascular outcomes of patients treated for cancer. This study aims to identify the chances of heart-related problems and find factors that predict cardiovascular events in cancer patients. It also seeks to create a biological collection for testing biomarkers and genetic factors linked to cardiovascular events during cancer treatment. Participants will be monitored for 5 years following a standardized cardio-oncology protocol based on international guidelines and drug-specific information. The study involves regular cardio-oncological follow-ups and management within specialized centers. Additional blood samples will be collected for biobanking. In some cases, a small skin biopsy may be performed to study the hearts response to immunotherapy using advanced cell models. Throughout the study, participants will have cardiac biomarkers measured at regular intervals over 5 years. Researchers will monitor heart health using clinical assessments, biological tests, and imaging methods. Data collected will help develop risk scores for cardiovascular events during cancer treatment. The study is led by Assistance Publique Hopitaux De Marseille and includes careful long-term follow-up and management of participants cardiovascular health.
CONDITIONS
Cardiovascular Outcome of Cancer Patients: The "GMEDICO Cohort"
F
franck thuny
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Assistance Publique Hopitaux De Marseille
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Initial period before follow-up
Participants undergo blood sample collection and may have a small skin biopsy to analyze cardiovascular response related to cancer treatment.
1 to 2 visits depending on assessments
Duration - 5 years
Participants are monitored for cardiovascular outcomes and biomarker levels over 5 years with cardio-oncological follow-up and management following established protocols.
Regular visits as per cardio-oncology follow-up protocol
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Have more questions? Get in touch with our team for quick support
Charles Dolladille, Stephane Ederhy, Stéphane Allouche...
https://pubmed.ncbi.nlm.nih.gov/31988143/Assistance Publique Hopitaux De Marseille
Lead Sponsor