Digital integration between hospitals and local health authorities for enhanced vaccination coverage among frail patients: the CareVax study protocol.
Alberto Lontano, Luca Regazzi, Diego Maria Tona...
https://pubmed.ncbi.nlm.nih.gov/39949559Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID06127563
Caring for Frail Patients Through Vaccination
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-08-12
1500
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a clinical pathway designed to improve vaccination rates among frail patients at Fondazione Policlinico Universitario "A. Gemelli" IRCCS. The study focuses on increasing immunization against pneumococcal disease, herpes zoster, influenza, hepatitis B virus, and COVID-19 to reduce hospital stays, long-term complications, and deaths. This approach aligns with the National Plan for Vaccine Prevention and recent Ministry of Health guidelines from 2017 to 2023. The intervention uses an automated algorithm applied to patients' electronic health records and vaccination histories to identify those eligible for vaccination. Depending on their frailty, patients will be invited for vaccination either at hospital vaccine clinics for extremely vulnerable individuals or at Local Health Unit clinics for other frail patients. The study also includes validating the algorithm's agreement with clinician judgments and establishing a digital system for booking and reminding patients about vaccination appointments. Participants will be monitored up to 24 months, with assessments including vaccination rates at 6, 12, and 24 months for influenza, COVID-19, hepatitis B, herpes zoster, and pneumococcus. Researchers will evaluate the algorithm's accuracy, feasibility of reaching patients, acceptability of the vaccination offer, logistical aspects of the vaccination process, and patient dropout rates. The study aims to enhance communication with patients and improve vaccination coverage through coordinated care between hospital and local services.
CONDITIONS
Brief Title
Caring for Frail Patients Through Vaccination
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- 18 years old or more
- Patients who have accessed one of the enrolled departments (Dermatology, Oncological gynaecology, Geriatry, Nephrology, Gastroenterology)
- Medical residence in Lazio Region
You will not qualify if you...
- Patients who do not fulfill one or more inclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surveillance
Duration - Up to 24 months
Participants who undergo routine care are observed for vaccination status and adherence to the clinical pathway over time.
Assessments at 6, 12, and 24 months
Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Lazio, Italy, 00168
Actively Recruiting
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Research Team
P
Patrizia Laurenti
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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