Actively Recruiting

Phase Not Applicable
Age: 18Years - 35Years
FEMALE
NCT07037017

CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa

Led by Istanbul Nisantasi University · Updated on 2025-06-25

60

Participants Needed

1

Research Sites

21 weeks

Total Duration

On this page

Sponsors

I

Istanbul Nisantasi University

Lead Sponsor

U

Uskudar University

Collaborating Sponsor

AI-Summary

What this Trial Is About

This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiological and attentional mechanisms related to body image disturbance and food-related anxiety in AN, contributing to biomarker-informed psychotherapy approaches.

CONDITIONS

Official Title

CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa

Who Can Participate

Age: 18Years - 35Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Female participants aged 18 to 35
  • Diagnosed with restrictive-type anorexia nervosa according to DSM-5
  • Body Mass Index (BMI) between 15.0 and 18.5
  • Medically stable to participate in psychological and neurophysiological assessments
  • Willing to attend weekly therapy sessions (for the CBT group) and complete pre- and post-assessments
  • Able to provide informed consent
Not Eligible

You will not qualify if you...

  • Current or past diagnosis of bulimia nervosa, binge-eating disorder, or other eating disorders
  • Severe psychiatric disorders such as psychosis, bipolar disorder, or substance use disorder
  • History of neurological illness or traumatic brain injury
  • Use of psychotropic medication within the last 6 weeks
  • Previous participation in structured Cognitive-Behavioral Therapy for an eating disorder
  • Pregnancy
  • Visual or neurological impairments preventing accurate EEG, GSR, or eye-tracking recordings

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Üsküdar University Neuro Marketing Lab.

Istanbul, Turkey (Türkiye)

Actively Recruiting

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Research Team

M

Metin Çınaroğlu, Phd

CONTACT

S

Selami Varol Ülker, Phd

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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