Actively Recruiting
Led by Istanbul Nisantasi University · Updated on 2025-06-25
60
Participants Needed
1
Research Sites
4 weeks
Total Duration
I
Istanbul Nisantasi University
Lead Sponsor
U
Uskudar University
Collaborating Sponsor
Researchers are evaluating the effects of Cognitive-Behavioral Therapy (CBT) on brain activity, physiological responses, and attention in females aged 18 to 35 with restrictive-type anorexia nervosa (AN). This trial compares a 12-week CBT program to a waitlist group receiving no active treatment. The study aims to understand how CBT influences neural markers related to attention and emotional processing, physiological arousal, and visual attention to food and body images, helping to develop biomarker-informed treatments for AN. Participants in the CBT group will attend weekly 60-minute individual therapy sessions targeting body image distortion, maladaptive thoughts, emotional regulation, and food-related avoidance behaviors. Both the CBT and waitlist groups undergo baseline and 12-week follow-up assessments including electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while viewing images related to self-appearance, food, and other female bodies. The study will measure changes in neural signals such as P300, Late Positive Potential, and frontal alpha asymmetry, as well as physiological arousal and gaze patterns. Throughout the study, participants complete psychometric questionnaires assessing eating disorder symptoms, depression, anxiety, obsessive-compulsive symptoms, and emotion regulation at baseline and after 12 weeks. Researchers will monitor neural and physiological changes alongside behavioral outcomes to understand CBT's impact. The total participation involves assessments before and after the 12-week intervention or observation period, providing insights into objective biomarkers of therapeutic change in AN.
CONDITIONS
CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants in the CBT group attend weekly 60-minute individual therapy sessions for 12 weeks targeting body image distortion, cognitive restructuring, emotional regulation, and exposure to food-related stimuli. The waitlist group does not receive therapy during this period.
Weekly visits for 12 weeks
Duration - Baseline and Week 12
Participants complete neurophysiological (EEG), physiological (GSR), and attentional (eye-tracking) assessments, along with psychometric questionnaires, at baseline and after 12 weeks to measure changes related to the intervention or waitlist period.
2 visits (in-person)
Total: 1 location
1
Üsküdar University Neuro Marketing Lab.
Istanbul, Turkey (Türkiye)
Actively Recruiting
M
Metin Çınaroğlu, Phd
S
Selami Varol Ülker, Phd
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Eda Yılmazer, Metin Çınaroğlu, Selami Varol Ülker...
https://pubmed.ncbi.nlm.nih.gov/41892652