Studying How Cerebral Small Vessel Disease Progresses After Different Types of Stroke Using Biomarkers and MRI

What this Trial Is About

Researchers are studying cerebral small vessel disease CSVD to understand how its development varies depending on the type of stroke a patient has experienced. This prospective observational study focuses on adults with known or newly diagnosed CSVD as seen on MRI scans. It aims to see if blood-based biomarkers, including some specific to the central nervous system, can provide additional insight into the progression of CSVD. The study also examines patient-important outcomes like cognitive abilities, neurological function, quality of life, and risk of stroke recurrence. Participants will be grouped based on MRI findings into those with CSVD without stroke, with acute lacunar ischemic stroke, or with acute territorial ischemic stroke. This study does not involve treatments but follows these groups over time to observe disease progression. Assessments include MRI evaluations and blood tests for biomarkers, along with various neurological and quality of life tests. During the study, participants will undergo MRI scans to measure changes in white matter lesions over one year. They will also have blood samples taken to track biomarker changes and assessments for neuropsychological performance, neurological function, stroke severity, daily activities, and quality of life. Researchers will monitor for any new cerebrovascular events and use ultrasound imaging to study neurovascular changes. The total participation lasts one year with regular follow-up visits to collect this information.

Cerebral Small Vessel Disease Progression Dependent on Stroke Type