Actively Recruiting
Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis: A Prospective Observation Pilot Study
Led by First Affiliated Hospital of Wannan Medical College · Updated on 2026-05-29
20
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with end-stage renal disease (ESRD) often develop arteriovenous graft (AVG) thrombosis, which can cause vascular access failure for hemodialysis. This study observes the effects of percutaneous transluminal angioplasty (PTA), a procedure used to restore blood flow in AVG thrombosis. Researchers aim to understand the immediate pulmonary consequences of thrombus fragmentation and revascularization by monitoring ventilation and perfusion changes using electrical impedance tomography (EIT). All participants will receive standard PTA treatment as part of their clinical care. During the procedure, a non-invasive 16-electrode EIT belt will be placed at the 4th intercostal level to continuously monitor regional lung ventilation and perfusion. Data collection will begin 10 minutes before PTA, continue during balloon dilation, and last up to 30 minutes after recanalization. No experimental drugs or devices beyond routine care will be used. Participants will undergo EIT monitoring at six time points: before PTA, at recanalization, and at 10, 20, 30 minutes after, plus at procedure completion. Researchers will assess ventilation-perfusion matching, oxygen saturation, physiological dead space, intrapulmonary shunt, and hemodynamic data. This observational study will help reveal short-term changes in lung function related to thrombus treatment during dialysis access restoration.
CONDITIONS
Brief Title
Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of end-stage renal disease receiving maintenance hemodialysis
- Documented arteriovenous graft thrombosis requiring percutaneous transluminal angioplasty
- Ability to cooperate and tolerate electrical impedance tomography monitoring
- Provided written informed consent
You will not qualify if you...
- Severe respiratory failure incompatible with lying on the back
- Thoracic skin condition or deformity preventing placement of EIT electrodes
- Acute pulmonary embolism or acute pulmonary edema before the procedure
- New York Heart Association Class IV heart failure or hemodynamic instability
- Pregnancy or breastfeeding
- Any other condition judged unsuitable by the investigator
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey: What to Expect
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 to 2 hours on the day of PTA
Participants undergo electrical impedance tomography (EIT) monitoring to record regional ventilation and perfusion continuously before, during, and after percutaneous transluminal angioplasty (PTA).
1 procedure visit (in-person) including continuous monitoring from 10 minutes before PTA through procedure completion
Duration - Up to 30 minutes post-procedure
Participants are observed for changes in ventilation-perfusion matching and related physiological measures during and immediately following the procedure.
Continuous monitoring during and up to 30 minutes after PTA
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
Wuhu, China
Actively Recruiting
Research Team
Q
qiancheng xu, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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