Monitoring Lung Ventilation and Blood Flow Changes After Balloon Angioplasty for Arteriovenous Graft Clot in Dialysis Patients

What this Trial Is About

Patients with end-stage renal disease ESRD often develop arteriovenous graft AVG thrombosis, which can cause vascular access failure for hemodialysis. This study observes the effects of percutaneous transluminal angioplasty PTA, a procedure used to restore blood flow in AVG thrombosis. Researchers aim to understand the immediate pulmonary consequences of thrombus fragmentation and revascularization by monitoring ventilation and perfusion changes using electrical impedance tomography EIT. All participants will receive standard PTA treatment as part of their clinical care. During the procedure, a non-invasive 16-electrode EIT belt will be placed at the 4th intercostal level to continuously monitor regional lung ventilation and perfusion. Data collection will begin 10 minutes before PTA, continue during balloon dilation, and last up to 30 minutes after recanalization. No experimental drugs or devices beyond routine care will be used. Participants will undergo EIT monitoring at six time points before PTA, at recanalization, and at 10, 20, 30 minutes after, plus at procedure completion. Researchers will assess ventilation-perfusion matching, oxygen saturation, physiological dead space, intrapulmonary shunt, and hemodynamic data. This observational study will help reveal short-term changes in lung function related to thrombus treatment during dialysis access restoration.

Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis