Actively Recruiting
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
Led by Zhujiang Hospital · Updated on 2024-12-27
2990
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational case-control study, aiming to systematically analyze the gut microbiome characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS). The study will collect blood and stool samples from MGUS patients, non-MGUS patients (with similar diseases), and healthy controls, and perform multi-omics detection including microbiomics, peptidomics, and biochemical immunology. It will comprehensively analyze the abnormal features of the gut microbiome in MGUS patients, which may help provide new biomarkers and potential mechanisms for the diagnosis, prognosis evaluation, and treatment strategies of MGUS.
CONDITIONS
Official Title
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 years or older
- Negative screening for monoclonal protein by MALDI-TOF MS
- No significant diseases found upon medical examination and no diseases related to this study
- Sufficient whole blood, plasma, serum, and stool samples available with relevant case data
You will not qualify if you...
- History of intestinal tumors, irritable bowel syndrome, or inflammatory bowel disease
- Antibiotic treatment in the past month
- Presence of severe systemic diseases including malignant tumors
- Insufficient sample volume or presence of severe hemolysis, lipemia, jaundice, or other unqualified sample conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhujiang Hospital of Southern Medical University
Guanzhou, Guangdong, China, 510280
Actively Recruiting
Research Team
N
Nianyi Zeng
CONTACT
H
Hongwei Zhou, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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