Actively Recruiting
Characterization of the Microbiome in Cutaneous T Cell Lymphoma
Led by Northwestern University · Updated on 2026-05-01
300
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the microbiome in people with cutaneous T cell lymphoma (CTCL) and comparing it to the microbiome of healthy individuals matched by age and sex. This pilot observational study aims to better understand how the microbial communities differ between these groups, including patients with various stages of CTCL, CD30+ lymphoproliferative disorders, plaque psoriasis, and moderate to severe atopic dermatitis, as well as healthy controls. Participants include several groups: those with different stages of CTCL, patients with CD30+ lymphoproliferative disorders, individuals with plaque psoriasis undergoing phototherapy, patients with atopic dermatitis using bleach bath therapy, and healthy volunteers without these conditions. The study does not involve treatments but focuses on observing and characterizing the skin microbiome in these populations. Participants will provide samples for microbiome analysis and be evaluated for bacterial diversity over three months. The study tracks bacterial diversity indices to understand microbial differences. Subjects must be between 18 and 89 years old and able to give informed consent. The total study period includes monitoring and sample collection to assess microbiome characteristics with no intervention or treatment provided during the study.
CONDITIONS
Brief Title
Characterization of the Microbiome in Cutaneous T Cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with stage IA-IIA cutaneous T cell lymphoma
- Patients with stage IIB and above cutaneous T cell lymphoma
- Patients with CD30+ lymphoproliferative disorders including lymphomatoid papulosis and cutaneous anaplastic large cell lymphoma
- Patients with plaque psoriasis with more than 5% body surface area on routine phototherapy
- Patients with moderate to severe atopic dermatitis on routine bleach bath therapy
- Healthy individuals without the above skin conditions, matched by age and sex
- Age between 18 and 89 years at time of enrollment
- Able and willing to give informed consent for this study and the Dermatology Tissue Acquisition and Biorepository
You will not qualify if you...
- Younger than 18 years or older than 90 years
- Unable to give consent
- Current or recent (within 4 weeks) use of systemic antibiotics
- Adults unable to consent, non-adults (infants, children, teenagers), pregnant women, prisoners, and other vulnerable populations
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 3 months
Participants provide skin microbiome samples and related data for analysis.
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
D
Dermatology CTU
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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