Actively Recruiting
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
Led by Rigshospitalet, Denmark · Updated on 2026-02-27
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a study to find out how common Cardiac Amyloidosis (CA) is in men aged 65 and older who have chest pain but no signs of coronary artery disease (CAD). This observational, prospective study includes patients who already had a CT coronary angiogram or Rb-PET scan to exclude CAD before joining. Participants will undergo several tests such as blood tests, urine samples, ECG, echocardiography, and bone scintigraphy to check for signs of CA. If needed, an endomyocardial biopsy may be performed to gather more information. This is not a drug trial but an assessment through examinations. During the study, researchers will carefully monitor participants using these tests to measure how often CA occurs in this group of men. The main outcome is to determine the prevalence of ATTR-CA within four weeks. The study is sponsored by Rigshospitalet, Denmark, and participation involves regular evaluations without treatment interventions.
CONDITIONS
Brief Title
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male gender
- Age 65 years or older
- Experiencing chest pain
- No signs of coronary artery disease based on Rb-PET and/or CT coronary arteriogram
You will not qualify if you...
- Previous history of amyloidosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) including clinical examination, blood samples, echo, and bone scintigraphy
Duration - Up to 4 weeks
Participants are observed to identify the presence of cardiac amyloidosis related to chest pain.
No additional visits beyond screening
Trial Site Locations
Total: 1 location
1
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
N
Navid Noory, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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