Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm.
Johannes Tobias Neumann, Nils Arne Sörensen, Tjark Schwemer...
https://pubmed.ncbi.nlm.nih.gov/27438315Actively Recruiting
Age: 18Years +
All Genders
ID02355457
Biomarkers in Acute Cardiac Care to Improve Diagnosis and Risk Assessment of Acute Coronary Syndrome
Led by Universitätsklinikum Hamburg-Eppendorf · Updated on 2024-05-13
5000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating new cardiac biomarkers and algorithms to improve the diagnosis of acute coronary syndrome (ACS) in people who may be experiencing an acute myocardial infarction, which is a type of heart attack. The study also aims to enhance ACS risk scores by including clinical, gender-specific, psychosocial, lifestyle factors, protein patterns, and genetic variability alongside traditional risk factors. This observational study also explores the impact of socio-economic factors on ACS and coronary artery disease risk. Participants are patients who have recently developed symptoms suggesting an acute myocardial infarction. During their hospital stay, researchers will collect data and samples such as DNA, RNA, cells, and blood plasma to perform genetic, gene expression, and proteomic studies. The study will also use genome-wide analyses to identify new therapeutic targets and examine the role of candidate genes for ACS. Participants will be followed during their hospital stay and then contacted by telephone for follow-up at 30 days, 6 months, 24 months, and 48 months after the event. Researchers will measure the occurrence of acute myocardial infarction as the primary outcome and will also track mortality, heart failure, and quality of life over several years. This long-term follow-up helps to better understand ACS and its precursors.
CONDITIONS
Brief Title
Biomarkers in Acute Cardiac Care
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Symptoms suggestive of acute myocardial infarction
- Ability to provide written informed consent in accordance with Good epidemiological Practice and local legislation
- Individuals at least 18 years old
You will not qualify if you...
- Insufficient knowledge of the German language (able to understand and write the German language)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - During hospital stay
Participants undergo diagnostic evaluations to detect and evaluate new cardiac biomarkers and assess acute coronary syndrome risk.
Multiple visits during hospital stay
Long-term Monitoring
Duration - Up to 48 months
Participants are followed up by telephone to monitor heart health and outcomes over several years.
Telephone follow-up at 30 days, 6 months, 24 months, and 48 months
Trial Site Locations
Total: 1 location
1
Department of Cardiology, University Heart Center Hamburg
Hamburg, Germany, 20246
Actively Recruiting
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Research Team
J
Johannes T Neumann, MD
N
Nils Sörensen, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I.
Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda...
https://pubmed.ncbi.nlm.nih.gov/27903616Diagnostic validation of a novel high-sensitivity cardiac troponin T assay.
Ben Völschow, Bianca Strauß, Nils Arne Sörensen...
https://pubmed.ncbi.nlm.nih.gov/42008514Comparison of the European Society of Cardiology 0/1-Hour and High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome 0/2-or-0/3-Hour Algorithms for Rapid Myocardial Infarction Diagnosis: A Prospective Multicenter Study.
Jonas Glaeser, Pedro Lopez-Ayala, Caroline Kellner...
https://pubmed.ncbi.nlm.nih.gov/41706062Bedside echocardiography in patients with suspected acute myocardial infarction without ST elevation.
Paul Michael Haller, Alina Schock, Caroline Kellner...
https://pubmed.ncbi.nlm.nih.gov/40828180A Common Algorithm for Cardiac Troponin to Rule Out and Rule in Acute Myocardial Infarction.
Niklas Thieβen, John W Pickering, Caroline Kellner...
https://pubmed.ncbi.nlm.nih.gov/40021054Long-term outcome of patients presenting with myocardial injury or myocardial infarction.
Paul M Haller, Caroline Kellner, Nils A Sörensen...
https://pubmed.ncbi.nlm.nih.gov/37982865Rising and Falling High-Sensitivity Cardiac Troponin in Diagnostic Algorithms for Patients With Suspected Myocardial Infarction.
Paul M Haller, Nils A Sörensen, Tau S Hartikainen...
https://pubmed.ncbi.nlm.nih.gov/37158171Personalized diagnosis in suspected myocardial infarction.
Johannes Tobias Neumann, Raphael Twerenbold, Francisco Ojeda...
https://pubmed.ncbi.nlm.nih.gov/37131096Role of Copeptin and hs-cTnT to Discriminate AHF from Uncomplicated NSTE-ACS with Baseline Elevated hs-cTnT-A Derivation and External Validation Study.
Stephan von Haehling, Matthias Müller-Hennessen, Tania Garfias-Veitl...
https://pubmed.ncbi.nlm.nih.gov/37048135