Actively Recruiting
Children's Bipolar Network Treatment Trial I
Led by University of California, Los Angeles · Updated on 2026-02-05
80
Participants Needed
4
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
U
University of Pittsburgh
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of this study are to (1) identify and reliably diagnose youth (ages 9 to 19 yrs) with full bipolar disorder (BD) and BSDs, and (2) examine predictors (e.g., mood instability, inflammatory marker C-reactive protein) of clinical outcome over a 12 month period. Participating youth will initially complete a screening that includes a structured diagnostic interview and a baseline blood draw to measure inflammatory processes. Youth with BSD and parents (80 families) will be asked to participate in multiple follow up research visits with interviews, rating instruments, and questionnaires. Per established CBN guidelines, study psychiatrists will provide and track medication management and sites will also track psychosocial treatments. This study ultimately aims to further understanding of best practice pediatric BSD psychiatric and psychosocial treatments and development of a standardized and validated set of clinical tools for patient assessment, diagnosis, and tracking.
CONDITIONS
Official Title
Children's Bipolar Network Treatment Trial I
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Youth 9-19 years old
- Youth diagnosed with Bipolar disorder (I, II, Other Specified) or Cyclothymic Disorder by the study team during the diagnostic interview screening
- Youth is able to read and communicate in English to participate in treatment and assessments appropriate for ages 9 and up
- Youth has a caregiver able to participate regularly in assessment and treatment
- The participating caregiver can reliably read and communicate in English for consenting, assessment, and treatment unless translation services are regularly available
You will not qualify if you...
- Youth has a DSM-5 diagnosis of autism spectrum disorder
- Youth has a DSM-5 diagnosis of substance or alcohol abuse with impairment within the past 3 months
- Youth has a medical or psychiatric disorder that is life-threatening or requires immediate hospitalization or emergency treatment
- Evidence of recent sexual or physical abuse of the youth by legally responsible caregivers
- Evidence of recent intimate partner violence between caregivers responsible for the youth's care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University of California, Los Angeles, Max Gray Child and Adolescent Mood Disorders Program (CHAMP)
Los Angeles, California, United States, 90024
Actively Recruiting
2
University of Colorado Anschutz Medical Campus, Helen and Arthur E. Johnson Depression Center
Aurora, Colorado, United States, 80045
Enrolling by Invitation
3
University of Pittsburgh Child and Adolescent Bipolar Spectrum Services Clinic (CABS)
Pittsburgh, Pennsylvania, United States, 15213
Enrolling by Invitation
4
Virginia Commonwealth University Medical Center
Richmond, Virginia, United States, 23298
Enrolling by Invitation
Research Team
D
David J Miklowitz, PhD
CONTACT
D
Danielle M Denenny, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here