Enhanced Pronociceptive and Disrupted Antinociceptive Mechanisms in Nonspecific Chronic Neck Pain.
Josu Zabala Mata, Ion Lascurain-Aguirrebeña, Estíbaliz Dominguez López...
https://pubmed.ncbi.nlm.nih.gov/33351923/Actively Recruiting
Led by Ander Cervantes Benítez · Updated on 2026-08-10
100
Participants Needed
1
Research Sites
39 weeks
Total Duration
Researchers are examining the relationship between brain activity patterns and clinical features in adults with chronic non-specific neck pain. The study also evaluates how these clinical and brain function measures change after physiotherapy treatment. Additionally, a healthy control group without neck pain will be assessed to provide comparison data for interpreting brain function in those with chronic neck pain. Participants with chronic non-specific neck pain will receive a six-week physiotherapy program consisting of weekly sessions that include manual therapy targeting the cervical and thoracic spine, combined with a neck-specific home exercise plan focusing on neck flexor and extensor muscles. Baseline clinical, psychophysical, and 64-channel electroencephalographic EEG assessments will be conducted before treatment. These assessments will be repeated about one week after completing the intervention. Healthy controls will undergo similar baseline assessments but will not receive physiotherapy or post-treatment evaluations. Throughout the study, participants will complete questionnaires, pain mapping, sensory testing, and EEG recordings while seated comfortably. Clinical outcomes such as pain intensity, neck disability, psychological factors, and sleep quality will be monitored at baseline, shortly after treatment, and 12 weeks following the last physiotherapy session. The primary outcome is measured by the Global Rating of Change scale. This approach allows researchers to track both immediate and longer-term effects of physiotherapy on clinical symptoms and brain activity in chronic neck pain.
CONDITIONS
Clinical and Brain Activity Assessment Before and After Physiotherapy in People With Chronic Non-specific Neck Pain
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Ander Cervantes Benítez
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 week
Participants complete clinical questionnaires, pain mapping, sensory testing, and brain activity recording before starting physiotherapy.
1 visit (in-person)
Duration - 6 weeks
Participants with chronic neck pain receive six weekly sessions of manual physiotherapy and a neck-specific home exercise program.
Weekly visits
Duration - 1 week
Clinical, psychophysical, and brain activity assessments are repeated approximately one week after completing physiotherapy.
1 visit (in-person)
Duration - 1 day
Participants complete evaluations of recovery, pain, and disability approximately 12 weeks after the final treatment session.
1 visit (in-person or remote)
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/29175204/Ander Cervantes Benítez
Lead Sponsor