Study on Effects of Different Heart Pacemaker Implantation Sites in Adults with Bradyarrhythmias or Heart Failure

What this Trial Is About

Researchers are evaluating the long-term effectiveness and safety of cardiac pacing at different sites in patients with bradyarrhythmias and heart failure. The study aims to compare the benefits and drawbacks of pacing from various locations within the heart, such as the right atrial appendage, atrial septum, right atrial wall, His bundle, left bundle branch area, right ventricular apex, outflow tract, and left ventricular pacing via the coronary vein. This observational study addresses a gap in knowledge about which pacing sites provide the best outcomes in daily medical practice. Participants will receive pacemaker implantation with the pacing site chosen based on their individual condition. The study focuses on monitoring the effects of pacing at these different sites over time without assigning specific treatments randomly. There is no mention of separate study phases or extension periods. During the study, patients will be followed up for up to 60 months to track a composite outcome that includes cardiovascular death, myocardial infarction, and stroke events. Researchers will observe participants health status through regular visits and data collection related to these cardiovascular events. The study is led by the Second Affiliated Hospital, School of Medicine, Zhejiang University, and aims to gather real-world evidence on pacing site impact.

Clinical Study of Impact of Different Pacing Site in Patients