Follow-up Study With Brain Imaging and Blood Tests for Adults Aged 18 to 65 During the First Wave of COVID-19 in China

What this Trial Is About

Researchers are investigating the physical, mental, and blood profile changes in people during and after the first wave of COVID-19, focusing on mild and moderate cases. The study aims to create a database using simultaneous cortico-spinal magnetic resonance imaging to identify patients at high risk of long COVID and to help improve management strategies for neurological symptoms in China. This observational, cross-sectional, multicenter study includes participants with confirmed mild or moderate COVID-19 and healthy controls without COVID-19. Participants undergo behavioral psychology assessments, blood sample collection, and simultaneous cortico-spinal magnetic resonance imaging at the acute infection phase and at 3 and 12 months follow-up. Healthy controls complete the same assessments once at inclusion. Participants will provide information via neuropsychological scales and submit blood samples at local labs. The study measures changes in brain structure and function, fatigue, cognition, anxiety, depression, pain, sleep, and inflammatory markers at baseline, 3, and 12 months. Data collection helps build a detailed post-COVID-19 imaging and biomarker database. The total study duration includes follow-up assessments over one year after initial infection.

Cohort Follow-up of Epidemic and Neuroimaging for Patients During the 1st Wave of the COVID-19 in China