What is this study trying to find out about COVID-19?

This study aims to understand why some people have long-term lung problems like shortness of breath and fatigue after severe COVID-19 infection. Researchers want to identify the clinical and biological traits that cause these lasting effects. The Mayo Clinic is leading this research to help improve understanding of chronic lung issues post-COVID.

Who may be eligible for this COVID-19 clinical trial?

Adults aged 18 and older who had a confirmed COVID-19 infection may be eligible. The study includes people who were hospitalized with severe COVID-19 and those who had mild cases without hospitalization. People with significant lung disease or current smoking habits may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this COVID-19 clinical trial?

Study-related care, including all tests and visits, is provided at no cost. However, personal travel and related expenses may vary and are not guaranteed to be covered. Participants should plan for any travel costs when considering joining the trial.

Actively Recruiting

Age: 18Years +

All Genders

ID06006884

Uncover Mechanisms Underlying the Development of Chronic Lung Sequelae Post COVID-19

Led by Mayo Clinic · Updated on 2026-05-07

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating why some people experience lasting effects like shortness of breath and fatigue after severe COVID-19 infection. The study focuses on people who had severe COVID-19 requiring hospitalization and those with mild cases who fully recovered. Its goal is to understand the clinical, imaging, immune, molecular, and viral factors linked to long-term lung problems after COVID-19. Participants will visit the Mayo Clinic three times over about a year around 2-3 months, 6 months, and 12 months after their COVID-19 diagnosis. During these visits, they will undergo lung imaging with CT scans, pulmonary function tests, heart electrical activity checks with ECG, and 6-minute walk tests. Bronchoscopies with bronchoalveolar lavages BAL will be done at the first and third visits to collect lung samples. Blood samples will also be collected at all visits to study immune and molecular changes over time. Participants will complete quality of life questionnaires and receive comprehensive clinical evaluations at each visit. Researchers will analyze lung images, lung function, and biological samples to identify markers related to chronic lung conditions post-COVID-19. The study lasts about 12 months per participant, with ongoing monitoring of lung health and symptoms. The main outcome is to uncover traits linked to long-term lung problems following COVID-19 infection.

CONDITIONS

Brief Title

A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Adults aged 18 years or older at screening
PCR confirmed COVID-19 illness
For the sequelae group: hospitalization for COVID-19 and no prior history of interstitial lung disease or significant lung disease
Severity of illness categorized by oxygen needs or ICU admission
For the recovery group: mild or asymptomatic COVID-19 not requiring hospitalization
No ongoing respiratory or systemic symptoms for recovery group

You will not qualify if you...

Unable to provide informed consent
Pre-existing interstitial lung disease or chronic lung disease
Current cigarette smoking, vaping, or inhalation use
Immunocompromised due to certain medications
More than 20 pack-year smoking history
Chemotherapy or radiation therapy in the last two years
Pregnancy

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