Cohort of Patients With Systemic Sclerosis and Associated Biological Collection Within the Framework of the RESO Reference Centre for Rare Systemic Autoimmune Diseases

What this Trial Is About

Researchers are studying systemic sclerosis (SSc), a rare connective tissue disease marked by blood vessel problems and severe fibrosis. This disease's cause is not fully understood, and there are no current treatments. The study aims to observe the natural progression of SSc over five years by following a group of patients carefully documented with biological samples to support research. Participants with systemic sclerosis or very early signs of the disease will be part of the cohort. Researchers will collect blood samples from all patients and may collect skin biopsies, bronchoalveolar samples if lung flare-ups occur, and digestive biopsies if needed during standard care. These biological samples help understand the disease better and develop collaborations for future research. During the study, patients will be evaluated at the start and after 60 months to track changes in their clinical condition, including lung and kidney health, and disease activity scores. The study will monitor the development of lung hypertension, interstitial lung disease, and kidney crises, as well as treatment strategies. Participation involves providing samples and attending assessments over five years to help researchers learn about SSc progression and its effects.

Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre