Comparative Study Between Safety and Efficacy of High Versus Low Power HOLEP in Enucleation of the Prostate; Prospective Randomized Double Blind Trial

What this Trial Is About

Researchers are comparing two different power settings of Holmium laser enucleation of the prostate (HoLEP) in men with large prostates who require surgery due to benign prostatic hyperplasia. The study aims to evaluate the efficiency of low-power HoLEP against high-power HoLEP, focusing on benefits such as lower cost and fewer side effects like postoperative discomfort, urinary storage symptoms, and sexual impact. This is a prospective, randomized trial without masking. The treatments being compared are low-power HoLEP using a 2J/25Hz setting and high-power HoLEP using a 2J/50Hz setting, both performed with a 100W Versapulse laser device. Participants are randomly assigned to one of these two groups, and the procedures involve enucleation of the prostate tissue. This trial investigates which power setting is more efficient and has fewer complications. Participants will be monitored for enucleation efficiency measured within 3 hours of the procedure. Additional assessments include evaluating dysuria using a visual analog scale at 2 weeks and monitoring complications over 3 months. The study follows participants through these time points to understand treatment impact and safety. The total duration of involvement depends on these follow-up assessments.

Comparative Study Between Safety and Effectiveness of High Versus Low Power HOLEP