Squamous cell carcinoma invading the right temporomandibular joint in a Belgian mare.
Melanie Perrier, Tobias Schwarz, Olga Gonzalez...
https://pubmed.ncbi.nlm.nih.gov/21037891Completed
Phase 1
Age: 6Months - 20Years
All Genders
ID00000814
A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents With Advanced HIV Disease
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2021-10-28
390
Participants Needed
68
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To compare the antiviral activity, safety, toxicity, and steady-state pharmacokinetics of zidovudine, didanosine, and nevirapine used in combination in patients with HIV infection. The duration of clinical benefit from zidovudine (AZT) may be limited because of development of viral resistance to the drug. Use of combination antiretroviral therapy can potentially reduce viral load and prevent emergence of multidrug resistance.
CONDITIONS
Official Title
A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents With Advanced HIV Disease
Who Can Participate
Age: 6Months - 20Years
All Genders
Eligibility Criteria
You may qualify if you...
Inclusion Criteria
Concurrent Medication:
Allowed:
- Erythropoietin.
Concurrent Treatment:
Allowed:
- Transfusion.
Patients must have:
- Progressive HIV disease.
- At least 24 weeks prior cumulative nucleoside analog antiretroviral monotherapy or combination therapy.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
- Active malignancy requiring chemotherapy.
- Currently receiving therapy in an ACTG primary therapy or salvage protocol who have NOT met an endpoint on that study.
- Known intolerance (other than hematologic) or toxicity to ddI, AZT, or NVP at the doses used in this study.
Concurrent Medication:
Excluded (unless exemption made by study chair):
- Oral anticoagulants (warfarin, dicumarol).
- Oral contraceptives.
- Digitalis glycosides.
- Phenytoin.
- Theophylline.
Patients with the following prior conditions are excluded:
- History of clinical pancreatitis.
- History of grade 2 or worse peripheral neuropathy.
Prior Treatment:
Excluded:
- Acute treatment for a serious bacterial, viral, or opportunistic infection within 14 days prior to study entry.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 68 locations
1
Univ of Alabama at Birmingham Schl of Med / Pediatrics
Birmingham, Alabama, United States, 35294
Status Unknown
2
UCSD Med Ctr / Pediatrics / Clinical Sciences
La Jolla, California, United States, 920930672
Status Unknown
3
Long Beach Memorial (Pediatric)
Long Beach, California, United States, 90801
Status Unknown
4
Los Angeles County - USC Med Ctr
Los Angeles, California, United States, 90033
Status Unknown
5
Cedars Sinai / UCLA Med Ctr
Los Angeles, California, United States, 900481804
Status Unknown
6
UCLA Med Ctr / Pediatric
Los Angeles, California, United States, 900951752
Status Unknown
7
Harbor - UCLA Med Ctr / UCLA School of Medicine
Los Angeles, California, United States, 905022004
Status Unknown
8
Children's Hosp of Oakland
Oakland, California, United States, 946091809
Status Unknown
9
UCSF / Moffitt Hosp - Pediatric
San Francisco, California, United States, 941430105
Status Unknown
10
Children's Hosp of Denver
Denver, Colorado, United States, 802181088
Status Unknown
11
Univ of Connecticut / Farmington
Farmington, Connecticut, United States, 06032
Status Unknown
12
Yale Univ Med School
New Haven, Connecticut, United States, 06504
Status Unknown
13
Georgetown Univ Med Ctr
Washington D.C., District of Columbia, United States, 200072197
Status Unknown
14
Children's Hosp of Washington DC
Washington D.C., District of Columbia, United States, 200102916
Status Unknown
15
Howard Univ Hosp
Washington D.C., District of Columbia, United States, 20060
Status Unknown
16
Univ of Florida Health Science Ctr / Pediatrics
Jacksonville, Florida, United States, 32209
Status Unknown
17
Univ of Miami (Pediatric)
Miami, Florida, United States, 33161
Status Unknown
18
Emory Univ Hosp / Pediatrics
Atlanta, Georgia, United States, 30306
Status Unknown
19
Cook County Hosp
Chicago, Illinois, United States, 60612
Status Unknown
20
Univ of Illinois College of Medicine / Pediatrics
Chicago, Illinois, United States, 60612
Status Unknown
21
Chicago Children's Memorial Hosp
Chicago, Illinois, United States, 606143394
Status Unknown
22
Univ of Chicago Children's Hosp
Chicago, Illinois, United States, 606371470
Status Unknown
23
Tulane Univ / Charity Hosp of New Orleans
New Orleans, Louisiana, United States, 701122699
Status Unknown
24
Univ of Maryland at Baltimore / Univ Med Ctr
Baltimore, Maryland, United States, 21201
Status Unknown
25
Johns Hopkins Hosp - Pediatric
Baltimore, Maryland, United States, 212874933
Status Unknown
26
Children's Hosp of Boston
Boston, Massachusetts, United States, 021155724
Status Unknown
27
Baystate Med Ctr of Springfield
Springfield, Massachusetts, United States, 01199
Status Unknown
28
Univ of Massachusetts Med School
Worcester, Massachusetts, United States, 016550001
Status Unknown
29
Children's Hosp of Michigan
Detroit, Michigan, United States, 48201
Status Unknown
30
UMDNJ - Robert Wood Johnson Med School / Pediatrics
New Brunswick, New Jersey, United States, 089030019
Status Unknown
31
Saint Joseph's Hosp and Med Ctr/UMDNJ - New Jersey Med Schl
Newark, New Jersey, United States, 07103
Status Unknown
32
Children's Hosp at Albany Med Ctr
Albany, New York, United States, 12208
Status Unknown
33
King's County Hosp Ctr / Pediatrics
Brooklyn, New York, United States, 11203
Status Unknown
34
SUNY - Brooklyn
Brooklyn, New York, United States, 11203
Status Unknown
35
North Shore Univ Hosp
Great Neck, New York, United States, 11021
Status Unknown
36
Schneider Children's Hosp
New Hyde Park, New York, United States, 11040
Status Unknown
37
Beth Israel Med Ctr / Pediatrics
New York, New York, United States, 10003
Status Unknown
38
Bellevue Hosp / New York Univ Med Ctr
New York, New York, United States, 10016
Status Unknown
39
Cornell Univ Med College
New York, New York, United States, 10021
Status Unknown
40
Metropolitan Hosp Ctr
New York, New York, United States, 10029
Status Unknown
41
Mount Sinai Med Ctr / Hemophilia Treatment Ctr
New York, New York, United States, 10029
Status Unknown
42
Mount Sinai Med Ctr / Pediatrics
New York, New York, United States, 10029
Status Unknown
43
Columbia Presbyterian Med Ctr
New York, New York, United States, 10032
Status Unknown
44
Incarnation Children's Ctr / Columbia Presbyterian Med Ctr
New York, New York, United States, 10032
Status Unknown
45
Harlem Hosp Ctr
New York, New York, United States, 10037
Status Unknown
46
Univ of Rochester Medical Center
Rochester, New York, United States, 14642
Status Unknown
47
State Univ of New York at Stony Brook
Stony Brook, New York, United States, 117948111
Status Unknown
48
SUNY Health Sciences Ctr at Syracuse / Pediatrics
Syracuse, New York, United States, 13210
Status Unknown
49
Bronx Lebanon Hosp Ctr
The Bronx, New York, United States, 10457
Status Unknown
50
Bronx Municipal Hosp Ctr / Bronx Lebanon Hosp Ctr
The Bronx, New York, United States, 10461
Status Unknown
51
Westchester Hosp
Valhalla, New York, United States, 10595
Status Unknown
52
Duke Univ Med Ctr
Durham, North Carolina, United States, 277103499
Status Unknown
53
Univ of North Carolina at Chapel Hill / Duke Univ Med Ctr
Durham, North Carolina, United States, 27710
Status Unknown
54
Columbus Children's Hosp
Columbus, Ohio, United States, 432052696
Status Unknown
55
West Central Ohio Hemophilia Ctr / Children's Med Ctr
Dayton, Ohio, United States, 454041815
Status Unknown
56
Milton S Hershey Med Ctr
Hershey, Pennsylvania, United States, 170330850
Status Unknown
57
Univ of Pittsburgh Med School / Hershey Med Ctr
Hershey, Pennsylvania, United States, 170330850
Status Unknown
58
Children's Hosp of Philadelphia
Philadelphia, Pennsylvania, United States, 191044318
Status Unknown
59
Saint Christopher's Hosp for Children
Philadelphia, Pennsylvania, United States, 191341095
Status Unknown
60
Rhode Island Hosp / Brown Univ
Providence, Rhode Island, United States, 02903
Status Unknown
61
Med Univ of South Carolina
Charleston, South Carolina, United States, 294253312
Status Unknown
62
Children's Med Ctr of Dallas
Dallas, Texas, United States, 75235
Status Unknown
63
Texas Children's Hosp / Baylor Univ
Houston, Texas, United States, 77030
Status Unknown
64
Children's Hosp of the King's Daughters
Norfolk, Virginia, United States, 23507
Status Unknown
65
Children's Hospital & Medical Center / Seattle ACTU
Seattle, Washington, United States, 981050371
Status Unknown
66
Ramon Ruiz Arnau Univ Hosp / Pediatrics
Bayamón, Puerto Rico, 00956
Status Unknown
67
Univ of Puerto Rico / Univ Children's Hosp AIDS
San Juan, Puerto Rico, 009365067
Status Unknown
68
San Juan City Hosp
San Juan, Puerto Rico, 009367344
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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