Actively Recruiting
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Led by National Cancer Institute (NCI) · Updated on 2026-05-13
153
Participants Needed
177
Research Sites
172 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II MyeloMATCH treatment trial compares cytarabine with daunorubicin versus cytarabine with daunorubicin and venetoclax versus venetoclax with azacitidine for the treatment of younger patients with intermediate risk acute myeloid leukemia (AML). Cytarabine is a drug that inhibits some of the enzymes needed for deoxyribonucleic acid (DNA) replication and repair and can slow or stop the growth of cancer cells. Daunorubicin is a drug that blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Azacitidine is a drug that interacts with DNA to activate tumor-suppressing genes, resulting in an anti-tumor effect. Adding venetoclax to cytarabine and daunorubicin, and adding venetoclax to azacitidine, may work better than the usual treatment of cytarabine with daunorubicin alone. To decide if they are better, the study doctors are looking to see if venetoclax increases the rate of elimination of AML in participants by 20% or more compared to the usual approach.
CONDITIONS
Official Title
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient must be enrolled in MYELOMATCH and assigned to this trial based on an actionable mutation
- Registered to master screening and re-assessment protocol (myeloMATCH MSRP) before consenting
- Agreed to submit specimens for translational medicine and future research
- Previously untreated, de novo AML with >20% myeloblasts excluding favorable cytogenetics and certain mutations
- Age between 18 and 59 years at induction therapy
- ECOG performance status of 0 to 3
- Total bilirubin less than or equal to 2 times institutional upper limit of normal within 7 days of enrollment
- AST and/or ALT less than or equal to 3 times institutional upper limit of normal within 7 days of enrollment
- Cardiac ejection fraction of 50% or higher within 14 days if clinically indicated
- Creatinine clearance of at least 30 mL/min/1.73m2 within 7 days of enrollment
- White blood cell count less than 25 x 10^9/L before starting protocol therapy
- Patients with prior or concurrent malignancy that does not interfere with safety or efficacy assessment
- Cardiac function classified as New York Heart Association class 2B or better
- Males and females of reproductive potential must agree to use highly effective contraception during and 6 months after treatment
- Women of childbearing potential must have a negative pregnancy test before study
- Provided informed consent as per regulatory requirements
- Must be accessible for treatment, response assessment, and follow-up at participating center
- Protocol treatment to begin within 7 working days of enrollment
- Participants on strong or moderate CYP3A inhibitors must discontinue use 48 hours before treatment if assigned to arm 1 or 2
- Patients with HIV on effective antiretroviral therapy with undetectable viral load within 6 months
- Patients with chronic hepatitis B infection must have undetectable viral load and be on suppressive therapy if needed
- Patients with treated and cured hepatitis C or undetectable viral load if currently treated
You will not qualify if you...
- Prior therapy for AML except hydroxyurea and leukapheresis
- Receiving other investigational agents
- History of allergic reactions to cytarabine, daunorubicin, azacitidine, or venetoclax
- Pregnant or breastfeeding women
- Patients with isolated myeloid sarcoma
- Any serious illness, life-threatening condition, organ dysfunction, or medical condition compromising safety
- Active, uncontrolled bacterial, fungal, or viral infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 177 locations
1
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Banner University Medical Center - Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
3
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States, 85719
Actively Recruiting
4
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Actively Recruiting
5
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States, 94704
Suspended
6
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
7
UCSF Medical Center-Parnassus
San Francisco, California, United States, 94143
Actively Recruiting
8
Miami Cancer Institute
Miami, Florida, United States, 33176
Actively Recruiting
9
Memorial Hospital West
Pembroke Pines, Florida, United States, 33028
Actively Recruiting
10
Phoebe Putney Memorial Hospital
Albany, Georgia, United States, 31701
Actively Recruiting
11
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, United States, 83706
Actively Recruiting
12
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
13
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, United States, 83605
Actively Recruiting
14
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, United States, 83814
Actively Recruiting
15
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, United States, 83619
Actively Recruiting
16
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, United States, 83642
Actively Recruiting
17
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, United States, 83687
Actively Recruiting
18
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, United States, 83687
Actively Recruiting
19
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States, 83854
Actively Recruiting
20
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States, 83864
Actively Recruiting
21
Centralia Oncology Clinic
Centralia, Illinois, United States, 62801
Actively Recruiting
22
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
23
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Actively Recruiting
24
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States, 62526
Actively Recruiting
25
Decatur Memorial Hospital
Decatur, Illinois, United States, 62526
Actively Recruiting
26
Crossroads Cancer Center
Effingham, Illinois, United States, 62401
Actively Recruiting
27
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, United States, 60201
Actively Recruiting
28
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, United States, 60026
Actively Recruiting
29
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, United States, 60035
Actively Recruiting
30
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
31
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, United States, 60451
Actively Recruiting
32
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States, 62269
Actively Recruiting
33
University of Chicago Medicine-Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
34
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
35
Springfield Clinic
Springfield, Illinois, United States, 62702
Actively Recruiting
36
Springfield Memorial Hospital
Springfield, Illinois, United States, 62781
Actively Recruiting
37
UChicago Medicine Northwest Indiana
Crown Point, Indiana, United States, 46307
Actively Recruiting
38
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
39
University of Kansas Clinical Research Center
Fairway, Kansas, United States, 66205
Actively Recruiting
40
University of Kansas Cancer Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
41
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, United States, 66211
Actively Recruiting
42
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States, 66205
Actively Recruiting
43
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
Actively Recruiting
44
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States, 40202
Actively Recruiting
45
UofL Health Medical Center Northeast
Louisville, Kentucky, United States, 40245
Actively Recruiting
46
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, United States, 70805
Actively Recruiting
47
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
48
Our Lady of The Lake
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
49
MaineHealth Maine Medical Center - Portland
Portland, Maine, United States, 04102
Actively Recruiting
50
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine, United States, 04074
Actively Recruiting
51
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, Maine, United States, 04106
Actively Recruiting
52
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Actively Recruiting
53
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
54
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
55
Lahey Hospital and Medical Center
Burlington, Massachusetts, United States, 01805
Actively Recruiting
56
Lahey Medical Center-Peabody
Peabody, Massachusetts, United States, 01960
Actively Recruiting
57
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
58
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, United States, 48188
Actively Recruiting
59
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
60
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States, 48038
Actively Recruiting
61
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
62
Cancer Hematology Centers - Flint
Flint, Michigan, United States, 48503
Actively Recruiting
63
Genesee Hematology Oncology PC
Flint, Michigan, United States, 48503
Suspended
64
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Actively Recruiting
65
Hurley Medical Center
Flint, Michigan, United States, 48503
Actively Recruiting
66
Allegiance Health
Jackson, Michigan, United States, 49201
Actively Recruiting
67
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States, 48154
Actively Recruiting
68
Henry Ford Medical Center-Columbus
Novi, Michigan, United States, 48377
Actively Recruiting
69
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, United States, 48341
Actively Recruiting
70
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
Actively Recruiting
71
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, United States, 48197
Actively Recruiting
72
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
73
Essentia Health - Deer River Clinic
Deer River, Minnesota, United States, 56636
Actively Recruiting
74
Essentia Health Cancer Center
Duluth, Minnesota, United States, 55805
Actively Recruiting
75
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Actively Recruiting
76
Essentia Health Hibbing Clinic
Hibbing, Minnesota, United States, 55746
Actively Recruiting
77
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
78
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
79
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
80
United Hospital
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
81
Essentia Health Sandstone
Sandstone, Minnesota, United States, 55072
Actively Recruiting
82
Essentia Health Virginia Clinic
Virginia, Minnesota, United States, 55792
Actively Recruiting
83
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, United States, 39705
Actively Recruiting
84
Baptist Cancer Center-Grenada
Grenada, Mississippi, United States, 38901
Actively Recruiting
85
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, United States, 38652
Actively Recruiting
86
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, United States, 38655
Actively Recruiting
87
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, United States, 38671
Actively Recruiting
88
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
89
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
90
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
91
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
92
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States, 63136
Actively Recruiting
93
Community Hospital of Anaconda
Anaconda, Montana, United States, 59711
Actively Recruiting
94
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Actively Recruiting
95
Bozeman Health Deaconess Hospital
Bozeman, Montana, United States, 59715
Actively Recruiting
96
Benefis Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Actively Recruiting
97
Logan Health Medical Center
Kalispell, Montana, United States, 59901
Actively Recruiting
98
Community Medical Center
Missoula, Montana, United States, 59804
Actively Recruiting
99
Nebraska Medicine-Bellevue
Bellevue, Nebraska, United States, 68123
Actively Recruiting
100
Nebraska Medicine-Village Pointe
Omaha, Nebraska, United States, 68118
Actively Recruiting
101
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
102
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, United States, 89102
Suspended
103
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, United States, 89183
Suspended
104
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
105
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
106
Saint Barnabas Medical Center
Livingston, New Jersey, United States, 07039
Actively Recruiting
107
Monmouth Medical Center
Long Branch, New Jersey, United States, 07740
Actively Recruiting
108
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
109
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
110
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
111
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, United States, 07652
Actively Recruiting
112
Valley Health System Ridgewood Campus
Ridgewood, New Jersey, United States, 07450
Actively Recruiting
113
Community Medical Center
Toms River, New Jersey, United States, 08755
Actively Recruiting
114
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
115
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
116
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
117
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
118
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
119
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
120
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
121
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
122
Memorial Sloan Kettering Nassau
Uniondale, New York, United States, 11553
Actively Recruiting
123
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, United States, 28203
Actively Recruiting
124
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, United States, 28204
Actively Recruiting
125
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
126
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
127
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
128
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
129
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Actively Recruiting
130
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
131
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, United States, 97914
Actively Recruiting
132
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
133
Providence Saint Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
134
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
135
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
136
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Actively Recruiting
137
Lewistown Hospital
Lewistown, Pennsylvania, United States, 17044
Actively Recruiting
138
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
139
Reading Hospital
West Reading, Pennsylvania, United States, 19611
Actively Recruiting
140
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
141
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, United States, 29316
Actively Recruiting
142
Prisma Health Cancer Institute - Easley
Easley, South Carolina, United States, 29640
Actively Recruiting
143
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, United States, 29605
Actively Recruiting
144
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, United States, 29605
Actively Recruiting
145
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States, 29615
Actively Recruiting
146
Prisma Health Cancer Institute - Greer
Greer, South Carolina, United States, 29650
Actively Recruiting
147
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, United States, 29672
Actively Recruiting
148
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, United States, 38017
Actively Recruiting
149
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, United States, 38120
Actively Recruiting
150
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
151
Ben Taub General Hospital
Houston, Texas, United States, 77030
Actively Recruiting
152
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
153
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
154
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
155
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
156
Inova Schar Cancer Institute
Fairfax, Virginia, United States, 22031
Actively Recruiting
157
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
158
Swedish Cancer Institute-Edmonds
Edmonds, Washington, United States, 98026
Actively Recruiting
159
Swedish Cancer Institute-Issaquah
Issaquah, Washington, United States, 98029
Actively Recruiting
160
Swedish Medical Center-First Hill
Seattle, Washington, United States, 98122
Actively Recruiting
161
Duluth Clinic Ashland
Ashland, Wisconsin, United States, 54806
Actively Recruiting
162
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States, 54301
Actively Recruiting
163
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, United States, 54303
Actively Recruiting
164
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
Actively Recruiting
165
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
166
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, United States, 54482
Actively Recruiting
167
Marshfield Medical Center - Weston
Weston, Wisconsin, United States, 54476
Actively Recruiting
168
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
169
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
170
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Actively Recruiting
171
QEII Health Sciences Centre/Nova Scotia Health Authority
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
172
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8V 5C2
Actively Recruiting
173
CSSS Champlain-Charles Le Moyne
Greenfield Park, Quebec, Canada, J4V 2H1
Actively Recruiting
174
CIUSSSEMTL-Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
175
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
176
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico, 00927
Actively Recruiting
177
San Juan City Hospital
San Juan, Puerto Rico, 00936
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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